1094598-75-0

Basic information

• Product Name: SILDENAFIL N-OXIDE
• Synonyms: SILDENAFIL N-OXIDE;5-[2-Ethoxy-5-[(4-Methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one;Sildenafil EP IMpurity B;Sildenafil impurity B;Sildenafil Impurity 14
• CAS NO: 1094598-75-0
• Molecular Formula: C₂₂H₃₀N₆O₅S
• Molecular Weight: 490.5758
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1094598-75-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
• PKA: 4.57±0.20(Predicted)
• CAS DataBase Reference: SILDENAFIL N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: SILDENAFIL N-OXIDE(1094598-75-0)
• EPA Substance Registry System: SILDENAFIL N-OXIDE(1094598-75-0)

Safety Data

• Hazardous Substances Data: 1094598-75-0(Hazardous Substances Data)

Usage

Description

SILDENAFIL N-OXIDE is an impurity of Sildenafil citrate (S435000), which is a prodrug used for the treatment of erectile dysfunction.

Uses

Used in Pharmaceutical Industry:
SILDENAFIL N-OXIDE is used as an impurity in the production of Sildenafil citrate (S435000), a prodrug for the treatment of erectile dysfunction. Its presence in the prodrug may affect the efficacy and safety of the drug, and therefore, it is important to control its levels during the manufacturing process.

Upstream product

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Relevant articles and documents

SILDENAFIL N-OXIDE AS PRODRUG

Embodiments of the present invention relate to a compound of formula (1A) or a pharmacologically acceptable salt, hydrate, or solvate thereof. Other embodiments of the present invention relate to a pharmaceutical composition containing this com