109467-96-1

Basic information

• Product Name: Benzenemethanol, 2,6-dimethyl-4-(phenylmethoxy)-
• CAS NO: 109467-96-1
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol File: 109467-96-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2,6-dimethyl-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2,6-dimethyl-4-(phenylmethoxy)-(109467-96-1)
• EPA Substance Registry System: Benzenemethanol, 2,6-dimethyl-4-(phenylmethoxy)-(109467-96-1)

Safety Data

• Hazardous Substances Data: 109467-96-1(Hazardous Substances Data)

Usage

Primary Use

Treatment of allergies, hay fever, and the common cold

Mode of Action

Histamine antagonist; inhibits the effects of histamine in the body

Symptoms Alleviated

Sneezing, runny nose, itching, watery eyes

Additional Use

Sleep aid due to sedating effects

Side Effects

Drowsiness, dizziness, dry mouth, constipation

Caution

Should be used cautiously in individuals with certain medical conditions or who are taking other medications.

Upstream product

• 95741-45-0 4-(benzyloxy)-2,6-dimethylbenzoic acid 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 95741-44-9 1-((4-bromo-3,5-dimethylphenoxy)methyl)benzene 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 306297-02-9 4-benzyloxy-2,6-dimethylbenzoic acid methyl ester 
• 28924-92-7 4-(benzyloxy)-2,6-dimethylbenzaldehyde 

Downstream Products

• 341035-38-9 (4-benzyloxy-2,6-dimethyl-phenyl)-acetonitrile 
• 1416989-94-0 C₁₆H₁₇ClO 
• 1416989-95-1 C₂₄H₃₃NO₄S 
• 1416989-96-2 C₂₂H₂₉NO₄S 
• 955406-35-6 trifluoro-methanesulfonic acid 3,5-dimethyl-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester 
• 955406-32-3 (R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dimethyl-benzyl)-4-oxo-butyraldehyde 
• 955407-65-5 (R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one 
• 955406-33-4 (R)-3-(4-Benzyloxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one 
• 955406-34-5 (R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one 
• 301537-10-0 4-benzyloxy-2,6-dimethylbenzyl bromide 

Relevant articles and documents

Convenient, asymmetric synthesis of enantiomerically pure 2',6'- dimethyltyrosine (DMT) via alkylation of chiral equivalent of nucleophilic glycine

Asymmetric synthesis of (S)-2',6'-dimethyltyrosine (DMT) via reactions of 4'-benzyloxy-2',6'-dimethylbenzyl bromide with Ni(II)-complexes of the chiral Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]- benzophenone was developed. Inexpensive and readily available reagents and solvents involved, including recyclable chiral auxiliary, simplicity of the experimental procedures and high chemical yields, make this method synthetically attractive for preparing the target amino acids on a multi-gram scale. (C) 2000 Elsevier Science Ltd.

Unnatural chiral N - Tert -butanesulfinyl α-amino acid synthesis; A general synthetic strategy to N -boc-phenylalanine analogue alternatives

This work provides a general approach to unnatural chiral N-tert-butanesulfinyl α-amino acid synthesis with high yields and excellent diastereoselectivities (dr up to 98:2). The asymmetric addition of organometallic reagents to N-tert-butylsulfinyl imino acetate proceeded with excellent diastereo- and regioselectivities even on a 10 mmol scale. The sterically constrained 2,6-dimethyltyrosine (Dmt) derivative was also readily prepared from commercially available and inexpensive starting materials through simple steps. Georg Thieme Verlag Stuttgart · New York.

QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT1D/1B serotonin receptor ligands

Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.