1095-90-5 Usage
Description
Methadone hydrochloride, a synthetic narcotic, is an opioid with analgesic activity. It is a white solid and is regulated as a Schedule II compound in the United States. Methadone hydrochloride is primarily used in the treatment of opioid dependence and addiction.
Uses
Used in Pharmaceutical Industry:
Methadone hydrochloride is used as a treatment for opioid dependence, helping to control withdrawal symptoms and reduce cravings for opioids. It is particularly effective in managing opioid addiction due to its long-lasting effects and ability to stabilize patients during recovery.
Used in Research and Forensic Applications:
Methadone hydrochloride serves as an analytical reference material for research purposes, aiding in the development of new treatments and understanding the mechanisms of opioid addiction. It is also utilized in forensic applications to identify and analyze the presence of the drug in biological samples.
Brand Names:
Some common brand names for Methadone hydrochloride include Dolophine Hydrochloride (Roxane), Dolophine Hydrochloride (Xanodyne), Methadose (Mallinckrodt), and Westadone (Sandoz).
Originator
Dolophine ,Lilly,US,1947
Manufacturing Process
Diphenylacetonitrile is condensed with 2-chloro-1-dimethylaminopropane to give 4-(dimethylamino)-2,2-diphenyl valeronitrile. It is then reacted with ethyl magnesium bromide and then hydrolyzed using HCl to give methadone hydrochloride.
Therapeutic Function
Narcotic analgesic
Hazard
Toxic. Addictive narcotic. Use restricted.
Clinical Use
Treatment of opioid drug addiction
Analgesic for moderate to severe pain
Drug interactions
Metabolised in the liver to the Potentially hazardous interactions with other drugs
Analgesics: possible opioid withdrawal with
buprenorphine and pentazocine.
Antibacterials: metabolism increased by rifampicin;
increased risk of ventricular arrhythmias with
delamanid and telithromycin.
Antidepressants: concentration possibly increased
by fluoxetine, fluvoxamine, paroxetine and sertraline;
possible CNS excitation or depression with MAOIs
and moclobemide - avoid; possibly increased
sedative effects with tricyclics; concentration possibly
reduced by St John's wort.
Antiepileptics: concentration reduced by
carbamazepine, phenobarbital and phenytoin.
Antifungals: concentration increased by fluconazole,
ketoconazole, voriconazole and possibly itraconazole
- may need to reduce methadone dose with
voriconazole, avoid with ketoconazole.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antimalarials: increased risk of ventricular
arrhythmias with piperaquine with artenimol -
avoid.
Antipsychotics: enhanced hypotensive and sedative
effects; increased risk of ventricular arrhythmias with
antipsychotics that prolong the QT interval - avoid
with amisulpride.
Antivirals: methadone possibly increases
concentration of zidovudine; concentration
reduced by efavirenz, fosamprenavir and ritonavir;
concentration possibly reduced by abacavir,
nevirapine and rilpivirine; concentration possibly
affected by boceprevir; concentration of didanosine
possibly reduced; increased risk of ventricular
arrhythmias with saquinavir and telaprevir - avoid
with saquinavir and use with caution with telaprevir.
Atomoxetine: increased risk of ventricular
arrhythmias.
Cytotoxics: possible increased risk of ventricular
arrhythmias with bosutinib, ceritinib, panobinostat
and vandetanib.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid
Metabolism
Metabolised in the liver to the major metabolite
2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine
and the minor metabolite 2-ethyl-3,3-diphenyl-5-
methylpyrrolidine, both of them inactive. Two other
metabolites have also been identified.
These metabolites are excreted in the faeces and urine
with unchanged methadone
Purification Methods
The salt crystallises from EtOH, or EtOH/Et2O.
Check Digit Verification of cas no
The CAS Registry Mumber 1095-90-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,9 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1095-90:
(6*1)+(5*0)+(4*9)+(3*5)+(2*9)+(1*0)=75
75 % 10 = 5
So 1095-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO.2ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;;/h6-15,17H,5,16H2,1-4H3;2*1H