109522-62-5

Basic information

• Product Name: 2-ETHOXY-1,1-DIFLUOROOXOETHYLZINC BROMIDE
• Synonyms: 2-ETHOXY-1,1-DIFLUOROOXOETHYLZINC BROMIDE;2-Ethoxy-1,1-difluorooxoethylzinc bromide 0.5M in Tetrahydrofuran
• CAS NO: 109522-62-5
• Molecular Formula: C₄H₅BrF₂O₂Zn
• Molecular Weight: 268.37
• Mol File: 109522-62-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ETHOXY-1,1-DIFLUOROOXOETHYLZINC BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXY-1,1-DIFLUOROOXOETHYLZINC BROMIDE(109522-62-5)
• EPA Substance Registry System: 2-ETHOXY-1,1-DIFLUOROOXOETHYLZINC BROMIDE(109522-62-5)

Safety Data

• Hazardous Substances Data: 109522-62-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5F2O2.BrH.Zn/c1-2-8-4(7)3(5)6;;/h2H2,1H3;1H;/q;;+1/p-1/rC4H5BrF2O2Zn/c1-2-9-3(8)4(6,7)10-5/h2H2,1H3

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 7440-66-6 zinc 

Downstream Products

• 330801-21-3 ethyl 2,2-difluoro-3-hydroxy-4-phenylbutanoate 
• 92207-60-8 ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate 
• 252681-03-1 (4S)-3,3-difluoro-1-((1R)-2-hydroxy-1-phenylethyl)-4-phenylazetidin-2-one 
• 1255305-76-0 2,2-difluoro-2-(4-pyridyl)acetic acid ethyl ester 
• 1004305-97-8 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester 
• 166376-97-2 3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-difluoro-3-hydroxy-propionic acid ethyl ester 

Relevant articles and documents

Preparation method of gemcitabine intermediate

The invention relates to a preparing method of a gemcitabine intermediate, and belongs to the technical field of medicine intermediate synthesis. In order to solve the problems that an existing methodis violent in reaction and not stable in yield, the preparing method of the gemcitabine intermediate is provided. The method includes the steps of adding iodine powder to an organic zinc intermediate-state reaction solution obtained through the reaction of ethyl bromodifluoroacetate and activated zinc powder in a first solvent, adding acetonylidene glyceraldehyde to a second solvent to obtain a corresponding acetonylidene glyceraldehyde solution, synchronous pumping the organic zinc intermediate-state reaction solution and the acetonylidene glyceraldehyde solution into a micro-channel reactorfor a condensation reaction to obtain outflow liquid, and conducting acidification to obtain the corresponding product (gemcitabine intermediate). The problem of the violent reaction can be effectively overcome, and the effects of mild reaction and high product yield are achieved.

AZETIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Compounds of formula [I]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salts or solvates thereof.