1096296-85-3Relevant articles and documents
STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI
-
Page/Page column 101; 102, (2015/01/07)
The present invention relates to novel strobilurine type compounds I, processes for preparing these compounds, a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi, to compositions comprising at least one such compound, to plant health applications, and to seeds coated with at least one such compound.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Ameriks, Michael K.,Bembenek, Scott D.,Burdett, Matthew T.,Choong, Ingrid C.,Edwards, James P.,Gebauer, Damara,Gu, Yin,Karlsson, Lars,Purkey, Hans E.,Staker, Bart L.,Sun, Siquan,Thurmond, Robin L.,Zhu, Jian
scheme or table, p. 4060 - 4064 (2010/08/07)
A pyridazin-4-one fragment 4 (hCatS IC50 = 170 μM) discovered through Tethering was modeled into cathepsin S and predicted to overlap in S2 with the tetrahydropyridinepyrazole core of a previously disclosed series of CatS inhibitors. This fragment served as a template to design pyridazin-3-one 12 (hCatS IC50 = 430 nM), which also incorporates P3 and P5 binding elements. A crystal structure of 12 bound to Cys25Ser CatS led to the synthesis of the potent diazinone isomers 22 (hCatS IC50 = 60 nM) and 27 (hCatS IC50 = 40 nM).