1098189-00-4Relevant articles and documents
Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease
Sheng, X. Christopher,Appleby, Todd,Butler, Thomas,Cai, Ruby,Chen, Xiaowu,Cho, Aesop,Clarke, Michael O.,Cottell, Jeromy,Delaney IV, William E.,Doerffler, Edward,Link, John,Ji, Mingzhe,Pakdaman, Rowchanak,Pyun, Hyung-Jung,Wu, Qiaoyin,Xu, Jie,Kim, Choung U.
, p. 2629 - 2634 (2012)
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monke
METHODS FOR TREATING HCV
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Paragraph 0280, (2013/10/22)
This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.