109822-14-2

Basic information

• Product Name: 3-chloro-2H-[1,2'-bipyridin]-2-one
• Synonyms: 3-chloro-2H-[1,2'-bipyridin]-2-one
• CAS NO: 109822-14-2
• Molecular Weight: 206.631
• Mol File: 109822-14-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-chloro-2H-[1,2'-bipyridin]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2H-[1,2'-bipyridin]-2-one(109822-14-2)
• EPA Substance Registry System: 3-chloro-2H-[1,2'-bipyridin]-2-one(109822-14-2)

Safety Data

• Hazardous Substances Data: 109822-14-2(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 13466-35-8 3-chloro-2-hydroxypyridine 

Relevant articles and documents

Copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles

A copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles has been developed. The reaction proceeded smoothly by twofold C-H cleavage even in the absence of noble-metal catalysts. The observed site selectivity was directed by a pyridyl substituent on the nitrogen atom of the pyridone ring. This directing group was readily removed after the coupling event, thus leading to 2-pyridone derivatives with a free N-H group. Moreover, in some cases, catalytic turnover of the Cu salt was also possible with the ideal terminal oxidant: molecular oxygen in air. Appointment of a temporary director: A copper-mediated C6-selective dehydrogenative arylation of 2-pyridones with 1,3-azoles was developed with the aid of an attachable/detachable pyridine-based directing group (see scheme). The reaction proceeded effectively without a noble metal, and in some cases molecular oxygen in air rendered the process catalytic in copper.

Rhodium-Catalyzed/Copper-Mediated Tandem C(sp2)-H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2-a:3,4-a′]dipyridin-5-ium-4-olates from 2H-[1,2′-Bipyridin]-2-ones and Propargyl Alcohols

A rhodium-catalyzed/copper-mediated tandem C(sp2)-H alkynylation and intramolecular annulation of 2H-[1,2′-bipyridin]-2-ones with propargyl alcohols for the synthesis of 11-acylated imidazo[1,2-a:3,4-a′]dipyridin-5-ium-4-olates is described.