110115-07-6 Usage
Description
Calpain Inhibitor II, also known as a cell-permeable peptide, is a compound that effectively restricts the activity of calpain, cathepsin L, and cathepsin B. It is characterized by its white to off-white powder form and has the ability to inhibit activation-induced programmed cell death, restore defective immune responses in HIV+ donors, and prevent nitric oxide production by interfering with the transcription of the inducible nitric oxide synthase gene.
Uses
Used in Pharmaceutical Applications:
Calpain Inhibitor II is used as a therapeutic agent for its ability to inhibit calpain, cathepsin L, and cathepsin B, which are involved in various cellular processes. Its application in this industry is due to its potential to modulate cellular activities and provide targeted treatment for specific conditions.
Used in Neuroprotection:
Calpain Inhibitor II is used as a neuroprotective agent for preventing methylmercury-induced cell death in cultured rat cerebellar neurons. Its application in this field is attributed to its ability to protect neurons from toxic substances and maintain cellular integrity.
Used in HIV Treatment:
Calpain Inhibitor II is used as an immune response enhancer in HIV+ patients, helping to restore defective immune responses. Its application in this area is due to its capacity to improve the immune system's ability to fight off infections and maintain overall health.
Used in Inflammation and Nitric Oxide Regulation:
Calpain Inhibitor II is used as an anti-inflammatory agent and nitric oxide regulator, preventing the production of nitric oxide by activated macrophages. Its application in this field is based on its ability to interfere with the transcription of the inducible nitric oxide synthase gene, thus reducing inflammation and oxidative stress.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 110115-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,1,1 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 110115-07:
(8*1)+(7*1)+(6*0)+(5*1)+(4*1)+(3*5)+(2*0)+(1*7)=46
46 % 10 = 6
So 110115-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16+,17+/m1/s1
110115-07-6Relevant articles and documents
Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
-
, (2008/06/13)
Use of a compound represented by the following general formula (I): wherein R1 represents a straight or branched acyl group having 2 to 10 carbon atoms, a branched cyclic or bridged cyclic alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted or unsubstituted benzyloxycarbonyl group, a 2,2,2-trichloroethyloxycarbonyl group, a 2-(trimethylsilyl)-ethyloxycarbonyl group, a p-toluenesulfonyl group, an o-nitrophenylsulfenyl group, a diphenylphosphonothioyl group, a triphenylmethyl group, a 2-benzoyl-1-methylvinyl group or a 4-phenylbutanoyl group; R2 represents a hydrogen atom or forms a phthaloyl group together with R1; R3 represents an isobutyl group, an n-butyl group or an isopropyl group; R? represents an n-butyl group or an isobutyl group; X represents a direct bond, a methionine residue, a leucine residue or a norleucine residue; and H at the C-terminal means that the carboxyl group is reduced in the form of the aldehyde; as an active ingredient for the preparation of a pharmaceutical composition useful in preventing or treating malignant hypercalcemia, bone Paget's disease or osteoporosis.
