110480-87-0

Basic information

• Product Name: (R)-1-amino-2-methyl-1-phenyl-propan-2-ol
• Synonyms: (R)-1-amino-2-methyl-1-phenyl-propan-2-ol
• CAS NO: 110480-87-0
• Molecular Weight: 165.235
• Mol File: 110480-87-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (R)-1-amino-2-methyl-1-phenyl-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-amino-2-methyl-1-phenyl-propan-2-ol(110480-87-0)
• EPA Substance Registry System: (R)-1-amino-2-methyl-1-phenyl-propan-2-ol(110480-87-0)

Safety Data

• Hazardous Substances Data: 110480-87-0(Hazardous Substances Data)

Usage

Description

(R)-1-amino-2-methyl-1-phenyl-propan-2-ol, commonly known as ephedrine, is a chiral compound with the chemical formula C11H17NO. It is a naturally occurring alkaloid derived from plants of the Ephedra genus. As a sympathomimetic amine, ephedrine functions as a central nervous system stimulant and bronchodilator, making it a versatile compound with various applications in the medical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
Ephedrine is utilized as a medication for treating asthma, nasal congestion, and as a decongestant. Its bronchodilating properties help alleviate respiratory issues by relaxing the smooth muscles in the airways, improving airflow.
Used in Performance Enhancement:
Ephedrine is employed as a performance-enhancing drug due to its stimulant effects on the central nervous system. It can temporarily increase alertness, focus, and physical endurance, making it appealing to athletes and individuals seeking a competitive edge. However, its use for this purpose is controversial and regulated, as it can lead to abuse and adverse health effects.
Used in Weight Loss Supplements:
Ephedrine is also used in the weight loss industry as a supplement. Its stimulant properties can increase metabolism and energy expenditure, potentially aiding in weight loss. Nevertheless, its use in this context is similarly controversial and regulated due to the potential for misuse and negative health consequences.
Used as a Precursor in Illicit Drug Synthesis:
Ephedrine serves as a precursor chemical for the illegal production of methamphetamine. Due to its role in the synthesis of this dangerous drug, ephedrine has been subject to legal restrictions in many countries to prevent its diversion for illicit purposes.

Upstream product

• 17609-48-2 (R)-2-phenylglycine ethyl ester hydrochloride 
• 74-88-4 methyl iodide 
• 917-64-6 methyl magnesium iodide 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 223906-33-0 ((R)-2-hydroxy-2-methyl-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 10152-58-6 (-)-(2S)-1,1-dimethyl-2-phenylethylene oxide 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 100-52-7 benzaldehyde 
• 24461-61-8 (R)-Phenylglycine methyl ester 
• 875-74-1 (R)-phenylglycine 
• 1187993-00-5 2,2,2-Trifluoro-N-[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]acetamide 
• 141190-94-5 (R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester 

Downstream Products

• 170918-35-1 N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide 
• 1257614-06-4 (R)-5,5-dimethyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 
• 1610360-90-1 (R)-2,2-dimethyl-1-((2-nitrophenyl)sulfonyl)-3-phenylaziridine 
• 1610360-96-7 (R)-N-(2-hydroxy-2-methyl-1-phenylpropyl)-2-nitrobenzenesulfonamide 
• 1617545-81-9 (R)-1-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-2-methyl-1-phenyl-propan-2-ol 
• 220578-28-9 2,2'-methylenebis[(4R)-4-phenyl-5,5-dimethyl-2-oxazoline] 
• 170918-42-0 (R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone 
• 168298-08-6 (4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one 
• 360778-83-2 (R)-[2-(tert-Butyl-dimethyl-silanyloxy)-3,5-dimethoxy-4-methyl-phenyl]-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-acetic acid methyl ester 
• 360778-72-9 (3R,5R)-3-(7-Hydroxy-6-methoxymethoxy-benzo[1,3]dioxol-4-yl)-6,6-dimethyl-5-phenyl-morpholin-2-one 
• 360778-80-9 methanesulfonic acid 6-(6,6-dimethyl-2-oxo-5-phenylmorpholin-3-yl)-2,4-dimethoxy-3-methylphenyl ester 
• 360778-82-1 (R)-(2-Hydroxy-3,5-dimethoxy-4-methyl-phenyl)-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-acetic acid methyl ester 
• 360778-77-4 3-(2-hydroxy-3,5-dimethoxy-4-methylphenyl)-6,6-dimethyl-5-phenylmorpholin-2-one 

Relevant articles and documents

Regio- and Enantioselective Ni-Catalyzed Formal Hydroalkylation, Hydrobenzylation, and Hydropropargylation of Acrylamides to α-Tertiary Amides

The development of enantioselective alkyl–alkyl cross-couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermolecular regio- and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α-position to the newly formed Csp3–Csp3 bond for the first time. The use of a newly developed chiral ligand enables the electronically-reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α-stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti-Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.

NOVE PHENYL/PYRIDINE SERIES SUBSTITUED BY HYDROXYETHYLAMINO FOR THE TREATMENT OF CANCER

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and W are as described herein, compositions including the compounds and methods of using the compounds.

Substituted 4-Hydroxypyrimidine-5-Carboxamides

The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.