110707-74-9Relevant articles and documents
Substituted 3-(Phenylmethyl)-1H-indole-5-carboxamides and 1-(Phenylmethyl)indole-6-carboxamides as Potent, Selective, Orally Active Antagonists of the Peptidoleukotrienes
Jacobs, Robert T.,Brown, Frederick J.,Cronk, Laura A.,Aharony, David,Buckner, Carl K.,et al.
, p. 394 - 409 (2007/10/02)
Substituted indole-5-caboxamides and indole-6-carboxamides have been found to be potent and selective antagonists of the peptidoleukotrienes.Initial derivatives of these series (4--1-methylindol-3-yl>methyl>-3-methoxy-N-
Indole and indazole keto sulphones as leukotriene antagonists
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, (2008/06/13)
This invention provides a series of novel keto sulfones of formula I STR1 in which the group =A-- is selected from =C(Ra)-- and =N-- and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.