111060-65-2Relevant articles and documents
Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols
Neouchy, Zeina,Gomez Pardo, Domingo,Cossy, Janine
supporting information, p. 6017 - 6021 (2018/09/25)
The synthesis of various optically active α-trifluoromethylamines has been realized from β-amino-α-trifluoromethyl alcohols via an aziridinium ion intermediate under kinetic conditions.
A - And B -fluorinated aminophosphonates-Synthesis and properties
Ka?mierczak, Marcin,Kubicki, Maciej,Koroniak, Henryk
, p. 459 - 468 (2016/04/09)
Interest in synthesis of fluorinated aminophosphonates has grown significantly in recent years due to their promising applications in medicinal and bioorganic chemistry. We report herein efficient and general methods for the synthesis of α- and β-monofluo
Synthesis and identification of unprecedented selective inhibitors of CK1ε
Silveira-Dorta, Gastón,Sousa, Inês J.,Fernandes, Miguel X.,Martín, Victor S.,Padrón, José M.
, p. 308 - 317 (2015/04/27)
A small and structure-biased library of enantiopure anti-β-amino alcohols was prepared in a straightforward manner by a simplified version of the Reetz protocol. Antiproliferative activity testing against a panel of five human solid tumor cell lines gave GI50 values in the range 1-20 μM. The reverse screening by computational methods against 58 proteins involved in cancer pointed to kinases as possible therapeutic target candidates. The experimental determination of the interaction with 456 kinases indicated that the compounds behave as selective CK1ε inhibitors. Our results demonstrate that the lead compound represents the first selective CK1ε inhibitor with proven antiproliferative activity in cancer cell lines.
