1111636-35-1 Usage
Description
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]is a complex organic compound belonging to the pyrazole class. It is characterized by its unique molecular structure, which includes a pyrrole and pyrimidine ring system, and a difluoroethyl group. Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]has potential applications in the pharmaceutical industry due to its properties as a Raf inhibitor.
Uses
Used in Pharmaceutical Industry:
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]is used as a potential Raf inhibitor for the development of novel therapeutic agents. Raf inhibitors are important in the treatment of various cancers, as they target the Raf protein, which plays a crucial role in cell signaling pathways involved in tumor growth and progression. By inhibiting Raf, this compound may help in the development of targeted cancer therapies.
Used in Research and Development:
In addition to its potential pharmaceutical applications, Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]may also be utilized in research and development for the study of Raf signaling pathways and the development of new drugs targeting these pathways. Its unique structure and potential Raf inhibitory activity make it a valuable tool for understanding the molecular mechanisms underlying cancer development and progression.
Biochem/physiol Actions
PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.
Check Digit Verification of cas no
The CAS Registry Mumber 1111636-35-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,1,6,3 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1111636-35:
(9*1)+(8*1)+(7*1)+(6*1)+(5*6)+(4*3)+(3*6)+(2*3)+(1*5)=101
101 % 10 = 1
So 1111636-35-1 is a valid CAS Registry Number.
1111636-35-1Relevant articles and documents
PYRAZOLE COMPOUNDS
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Page/Page column 85-86, (2009/03/07)
The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.