111183-88-1

Basic information

• Product Name: 5-oxo-6-phenylhexanal
• Synonyms: 5-oxo-6-phenylhexanal
• CAS NO: 111183-88-1
• Molecular Weight: 190.242
• Mol File: 111183-88-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-oxo-6-phenylhexanal(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-6-phenylhexanal(111183-88-1)
• EPA Substance Registry System: 5-oxo-6-phenylhexanal(111183-88-1)

Safety Data

• Hazardous Substances Data: 111183-88-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 120-92-3 cyclopentanone 
• 1589-82-8 phenylmagnesium bromide 
• 2015-57-8 1-benzylcyclopentanol 
• 15507-35-4 1-benzylcyclopentene 

Downstream Products

• 40564-46-3 (±)-6-benzyltetrahydro-2H-pyran-2-one 2l 

Relevant articles and documents

Stereoselective synthesis of δ-lactones from 5-oxoalkanals via one-pot sequential acetalization, tishchenko reaction, and lactonization by cooperative catalysis of samarium ion and mercaptan

By the synergistic catalysis of samarium ion and mercaptan, a series of 5-oxoalkanals was converted to (substituted) δ-lactones in efficient and stereoselective manners. This one-pot procedure comprises a sequence of acetalization, Tishchenko reaction and lactonization. The deliberative use of mercaptan, by comparison with alcohol, is advantageous to facilitate the catalytic cycle. The reaction mechanism and stereochemistry are proposed and supported by some experimental evidence. Such samarium ion/mercaptan cocatalyzed reactions show the feature of remote control, which is applicable to the asymmetric synthesis of optically active δ-lactones. This study also demonstrates the synthesis of two insect pheromones, (2S,5R)-2-methylhexanolide and (R)-hexadecanolide, as examples of a new protocol for asymmetric reduction of long-chain aliphatic ketones.