1112937-27-5

Basic information

• Product Name: 4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
• Synonyms: 4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
• CAS NO: 1112937-27-5
• Molecular Weight: 234.297
• Mol File: 1112937-27-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine(1112937-27-5)
• EPA Substance Registry System: 4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine(1112937-27-5)

Safety Data

• Hazardous Substances Data: 1112937-27-5(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 137234-74-3 4-chloro-6-ethyl-5-fluoropyrimidine 

Downstream Products

• 1112937-29-7 4-(1-bromo-ethyl)-6-(phenylsulfanyl)-5-fluoropyrimidine 

Relevant articles and documents

PROCESS FOR PREPARING VORICONAZOLE

Optically pure voriconazole can be prepared in a high yield by a) subjecting 1-(2,4-difluorophenyl)-2(1H-1,2,4-triazol-1-yl)ethanone to Reformatsky-type coupling reaction with a substituted thiopyrimidine derivative to obtain a desired (2R,3S)/(2S,3R)-enantiomeric pair; b) removing the thiol derivative from the enantiomer to obtain racemic voriconazole; and c) isolating the racemic voriconazole by way of optical resolution using an optically active acid.