111359-74-1Relevant articles and documents
Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells
Wang, Shan,Tian, Yu,Lu, Shan,Wang, Ruiying,Shang, Hai,Zhang, Xuelian,Zhang, Chenyang,Sun, Guibo,Xu, Xudong,Sun, Xiaobo
, p. 15224 - 15228 (2019)
Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA). Acetaminophen (APAP) is a widely used non-steroidal anti-inflammatory drug for treating fever and headache. APAP is con
A GENERAL PROCEDURE FOR THE CATALYTIC HYDROGENOLYSIS OF N-BENZYLAMINES UNDER EXTREMELY MILD CONDITIONS.
Yoshida, Kiyoshi,Nakajima, Shigekazu,Wakamatsu, Takeshi,Ban, Yoshio,Shibasaki, Masakatsu
, p. 1167 - 1168 (1988)
A general procedure for debenzylation of N-benzylamines, which contain acid sensitive functional groups, by the catalytic hydrogenolysis using 20percent Pd(OH)2-C is reported.
METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
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Paragraph 00616; 00618; 00635; 00636, (2021/08/13)
The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.
Probe for determining gamma-glutamyltranspeptidase as well as synthesis method and application thereof
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Paragraph 0053-0057; 0071; 0074; 0079; 0082, (2021/09/04)
The invention discloses a fluorescent probe for determining gamma-glutamyltranspeptidase. The structural formula of the fluorescent probe is shown in the specification; and the fluorescent probe can realize the conversion of a fluorescence signal from wea