1114-92-7Relevant articles and documents
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Winstein,Buckles
, p. 2780,2784 (1942)
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Sequential Kinetic Resolution of (+/-)-2,3-Butanediol in Organic Solvent Using Lipase From Pseudomonas cepacia.
Caron, Gaetan,Kazlauskas, Romas J.
, p. 1995 - 2000 (1993)
Lipase from Pseudomonas capacia (PCL, Amano PS) catalyzed the enantioselective diacetylation of (+/-)-2,3-butanediol in vinyl acetate.Both acetylation steps favored the (R)-enantiomer (E1 = 12, E2 = 34), thus the reaction is a sequential kinetic resolution.The enantioselectivities of the two steps reinforced one another because both steps proceeded at comparable rates (S = 3) yielding an overall enantioselectivity of approximately 200.A synthetic-scale resolution starting from 2.7 g of (+/-)-2,3-butanediol yielded the diacetate ester of (R)-(-)-butanediol with 96percent ee (1.6 g, 30percent yield) and (S)-(+)-butanediol with 99percent ee (0.63 g, 23percentyield).This preparation is carried out entirely in organic solvent, thereby avoiding the difficult and low yield extraction of 2,3-butanediol from aqueous solution.
METHOD FOR PRODUCING 1,3-BUTADIENE FROM 1,4-BUTANEDIOL
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Paragraph 0076-0080, (2018/03/01)
A method for producing 1,3-butadiene from a 1,4-butanediol feedstock: One step for esterification of 1,4-butanediol,One step for pyrolysis of 1,4-butanediol diester, producing butadiene.
Adrenaline profiling of lipases and esterases with 1,2-diol and carbohydrate acetates
Wahler, Denis,Boujard, Olivier,Lefèvre, Fabrice,Reymond, Jean-Louis
, p. 703 - 710 (2007/10/03)
The adrenaline test for enzymes is a general back-titration procedure to detect 1,2-diols, 1,2-aminoalcohols and α-hydroxyketones reaction products of enzyme catalysis by colorimetry. The method was used to profile a series of esterases and lipases for their esterolytic activity on a series of carbohydrate and polyol acetates. Substrates were prepared by peracetylation and used for parallel microtiter-plate analysis of enzyme activities. This method can be used to achieve a rapid and automated characterization of a set of enzymes during HTS screening.