1116136-30-1

Basic information

• Product Name: 1-tosyl-1H-pyrrolo[3,2-b]pyridine
• Synonyms: 1-tosyl-1H-pyrrolo[3,2-b]pyridine
• CAS NO: 1116136-30-1
• Molecular Weight: 272.327
• Mol File: 1116136-30-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-tosyl-1H-pyrrolo[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tosyl-1H-pyrrolo[3,2-b]pyridine(1116136-30-1)
• EPA Substance Registry System: 1-tosyl-1H-pyrrolo[3,2-b]pyridine(1116136-30-1)

Safety Data

• Hazardous Substances Data: 1116136-30-1(Hazardous Substances Data)

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1116138-21-6 5-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.