111688-35-8 Usage
Description
(R)-5-Methyloxazolidin-2-one, also known as oxazolidinone, is a chemical compound characterized by a five-membered heterocyclic ring that includes both oxygen and nitrogen atoms. It is predominantly utilized as a fundamental building block in the realm of organic synthesis, with a particular focus on the creation of pharmaceuticals and agrochemicals. (R)-5-Methyloxazolidin-2-one is chiral, existing in two non-superimposable mirror-image forms, with the (R)-enantiomer being especially valuable due to its capacity to selectively catalyze a variety of organic reactions. Furthermore, (R)-5-Methyloxazolidin-2-one has garnered interest for its potential role as a chiral auxiliary in asymmetric synthesis, along with its demonstrated antibacterial and antifungal properties. Collectively, this versatile chemical compound holds a broad spectrum of applications within the domains of organic chemistry and pharmaceutical research.
Uses
Used in Pharmaceutical Industry:
(R)-5-Methyloxazolidin-2-one is used as a key building block for the synthesis of various pharmaceuticals, leveraging its ability to selectively catalyze organic reactions and contribute to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-5-Methyloxazolidin-2-one is employed as a crucial component in the synthesis of agrochemicals, playing a significant role in the production of pesticides and other agricultural products.
Used in Asymmetric Synthesis:
(R)-5-Methyloxazolidin-2-one is utilized as a chiral auxiliary in asymmetric synthesis, a technique that is vital for creating enantiomerically pure compounds, which are essential in various applications, including pharmaceuticals and materials science.
Used in Antibacterial and Antifungal Applications:
(R)-5-Methyloxazolidin-2-one is also studied for its potential applications as an antibacterial and antifungal agent, which could be beneficial in the development of new treatments for bacterial and fungal infections.
Check Digit Verification of cas no
The CAS Registry Mumber 111688-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,6,8 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 111688-35:
(8*1)+(7*1)+(6*1)+(5*6)+(4*8)+(3*8)+(2*3)+(1*5)=118
118 % 10 = 8
So 111688-35-8 is a valid CAS Registry Number.
111688-35-8Relevant articles and documents
Catalytic fluoride triggers dehydrative oxazolidinone synthesis from CO2
Takada, Yuki,Foo, Siong Wan,Yamazaki, Yusuke,Saito, Susumu
, p. 50851 - 50857 (2014)
Herein, catalytic fluoride (F-) is demonstrated to be a trigger for dehydrative immobilization of atmospheric pressure CO2, such that reaction of CO2 with β-amino alcohols derived from natural amino acids gives optically pure oxazolidinones in high yields. A synergistic combination of fluoride and organosilicon agents (e.g., Bu4NF + Ph3SiF or siloxanes) enhances the catalytic activity and functional group compatibility. This system lies at the interface between homogenous and heterogeneous catalysis, and may prove useful for the development of recoverable/reusable siloxane-based CO2 immobilization materials. This journal is
PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
-
Page/Page column 44, (2020/12/30)
Pyridine carbamates, pharmaceutical compositions containing pyridine carbamates, and uses of the pyridine carbamates and pharmaceutical compositions for modulating GluN2B receptors and for treating diseases, disorders, and medical conditions mediated by GluN2B receptor activity.
Dehydrative synthesis of chiral oxazolidinones catalyzed by alkali metal carbonates under low pressure of CO2
Foo, Siong Wan,Takada, Yuki,Yamazaki, Yusuke,Saito, Susumu
supporting information, p. 4717 - 4720 (2013/08/23)
Dehydrative synthesis of oxazolidinones from amino alcohols and CO 2 was achieved in the presence of alkali metal carbonates such as Cs2CO3 as catalyst. It is noteworthy that 1 atm of CO 2 is enough for the reaction to proceed and no special dehydrating agent is required in this system. A mechanstic study showed that the OH of amino alcohol acts as nucleophile and the OH in the carbamic acid moiety is liberated during the cyclization process.
