111829-72-2 Usage
Description
4-BROMO-2,6-DICHLOROBENZALDEHYDE is an organic compound with the molecular formula C7H3BrCl2O. It is an aromatic aldehyde derivative featuring a bromo and two chloro substituents at the 4th and 2nd positions, respectively, on a benzene ring. 4-BROMO-2,6-DICHLOROBENZALDEHYDE is known for its reactivity and is commonly used as a building block in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
4-BROMO-2,6-DICHLOROBENZALDEHYDE is used as a reactant for the preparation of heterocyclic zinc-binding ligands. These ligands serve as stabilizing agents for insulin compounds, which are crucial in the treatment and management of diabetes.
In the synthesis of heterocyclic zinc-binding ligands, 4-BROMO-2,6-DICHLOROBENZALDEHYDE plays a vital role in forming the desired molecular structure. The presence of the bromine and chlorine atoms in the molecule allows for further functionalization and modification, enabling the creation of a diverse range of ligands with varying properties and applications.
The use of 4-BROMO-2,6-DICHLOROBENZALDEHYDE in the pharmaceutical industry is particularly significant due to its potential in enhancing the stability and efficacy of insulin compounds. Insulin is a vital hormone that regulates blood sugar levels, and its proper functioning is essential for maintaining overall health. By acting as a stabilizing agent, the ligands derived from 4-BROMO-2,6-DICHLOROBENZALDEHYDE can help improve the shelf life, storage, and delivery of insulin, ultimately benefiting patients with diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 111829-72-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,8,2 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 111829-72:
(8*1)+(7*1)+(6*1)+(5*8)+(4*2)+(3*9)+(2*7)+(1*2)=112
112 % 10 = 2
So 111829-72-2 is a valid CAS Registry Number.
111829-72-2Relevant articles and documents
Diverse ortho-C(sp2)-H functionalization of benzaldehydes using transient directing groups
Liu, Xi-Hai,Park, Hojoon,Hu, Jun-Hao,Hu, Yan,Zhang, Qun-Liang,Wang, Bao-Long,Sun, Bing,Yeung, Kap-Sun,Zhang, Fang-Lin,Yu, Jin-Quan
supporting information, p. 888 - 896 (2017/05/16)
Pd-catalyzed C-H functionalizations promoted by transient directing groups remain largely limited to C-H arylation only. Herein, we report a diverse set of ortho-C(sp2)-H functionalizations of benzaldehyde substrates using the transient directing group strategy. Without installing any auxiliary directing group, Pd(II)-catalyzed C-H arylation, chlorination, bromination, and Ir(III)-catalyzed amidation, could be achieved on benzaldehyde substrates. The transient directing groups formed in situ via imine linkage can override other coordinating functional groups capable of directing C-H activation or catalyst poisoning, significantly expanding the scope for metal-catalyzed C-H functionalization of benzaldehydes. The utility of this approach is demonstrated through multiple applications, including late-stage diversification of a drug analogue.
PHARMACEUTICAL COMPOSITION CONTAINING OPTICALLY ACTIVE COMPOUND HAVING THROMBOPOIETIN RECEPTOR AGONIST ACTIVITY AND INTERMEDIATE THEREOF
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Page/Page column 19-20, (2010/06/11)
An optically active 4-phenylthiazole derivative having a thrombopoietin receptor agonist activity and a pharmaceutical composition containing the present compound as an active ingredient are created, and a platelet production regulating agent which can be