111854-71-8

Basic information

• Product Name: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]-2-propynylamino]-
• CAS NO: 111854-71-8
• Molecular Formula: C17H15N7O2
• Molecular Weight: 349.352
• Mol File: 111854-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]-2-propynylamino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]-2-propynylamino]-(111854-71-8)
• EPA Substance Registry System: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]-2-propynylamino]-(111854-71-8)

Safety Data

• Hazardous Substances Data: 111854-71-8(Hazardous Substances Data)

Upstream product

• 82318-25-0 N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamic acid 
• 107174-54-9 4-prop-2-ynylamino-benzoic acid 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 

Downstream Products

• 101760-56-9 N¹⁰-propargylpteroic acid 

Relevant articles and documents

Synthesis of 10-Propargylfolic Acid from 2-Amino-6-(bromomethyl)-4(1H)-pteridinone

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide (1) is readily converted to 2-amino-6-(bromomethyl)-4(1H)-pteridinone hydrobromide (2) by treatment with 48percent hydrobromic acid.Compound 2 is of interest for direct attachment of the (2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl group to appropriate side-chain precursors of analogues of folic acid, particularly those bearing functional groups incompatible with conditions required for hydrolytic deamination of the corresponding 2,4-diaminopteridine analogues.An example of the use of 2 in this connection is demonstrated through synthesis of 10-propargylfolic acid.