1118765-37-9

Basic information

• Product Name: (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide
• Synonyms: (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide
• CAS NO: 1118765-37-9
• Molecular Weight: 465.503
• Mol File: 1118765-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide(1118765-37-9)
• EPA Substance Registry System: (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide(1118765-37-9)

Safety Data

• Hazardous Substances Data: 1118765-37-9(Hazardous Substances Data)

Upstream product

• 7341-96-0 2-propynamide 
• 160096-59-3 4',4''-O,O-dimethylcurcumin 

Downstream Products

• 1118765-44-8 (E,E,E)-3-(3,5-bis(3,4-dimethoxystyryl)-1H-pyrazol-4-yl)acrylamide 

Relevant articles and documents

Synthesis and evaluation of electron-rich curcumin analogues

The natural product curcumin has long been recognized for its medicinal properties and is utilized for the treatment of many diseases. However, it remains unknown whether this activity is based on its presumably promiscuous scaffold, or if it results from the Michael acceptor properties of the α,β-unsaturated 1,3-diketone moiety central to its structure. To probe this issue, electron-rich pyrazole and isoxazole analogues were prepared and evaluated against two breast cancer cell lines, which resulted in the identification of several compounds that exhibit low micromolar to mid nanomolar anti-proliferative activity. A conjugate addition study was also performed to compare the relative electrophilicity of the diketone, pyrazole and isoxazole analogues.