112030-31-6

Basic information

• Product Name: 6-chloro-4-methyl-3-phenyl-coumarin
• Synonyms: 6-chloro-4-methyl-3-phenyl-coumarin
• CAS NO: 112030-31-6
• Molecular Weight: 270.715
• Mol File: 112030-31-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-methyl-3-phenyl-coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-methyl-3-phenyl-coumarin(112030-31-6)
• EPA Substance Registry System: 6-chloro-4-methyl-3-phenyl-coumarin(112030-31-6)

Safety Data

• Hazardous Substances Data: 112030-31-6(Hazardous Substances Data)

Upstream product

• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 103-80-0 phenylacetyl chloride 
• 1555-80-2 phenylacetic anhydride 
• 114-70-5 sodium phenylacetate 
• 129333-67-1 Phenyl-acetic acid 2-acetyl-4-chloro-phenyl ester 

Relevant articles and documents

Facile metal-free synthesis of 3-aryl-4-substituted coumarins from o-hydroxy carbonyl compounds

The intramolecular cyclization of the esters of salicylaldehyde, O-hydroxyacetophenones, methyl salicylate, and 2'-hydroxy chalcones by potassium hydroxide in pyridine leads to a short and convenient synthesis of 3,4-disubstituted coumarins. Twenty 3-phenyl coumarins were synthesized in 80-90% yields. No other by-product, such as 2-benzylchromone or-diketones, was observed the reactions. The mild reaction condition involves the removal of more acidic benzylic proton, which leads to a relatively cheap, nontoxic, metal-free method for the synthesis of 3-aryl-4-substituted coumarins. Copyrigh