1121633-45-1

Basic information

• Product Name: 6-bromopyrido[2,3-d]pyrimidin-4-amine
• Synonyms: 6-bromopyrido[2,3-d]pyrimidin-4-amine
• CAS NO: 1121633-45-1
• Molecular Weight: 225.047
• Mol File: 1121633-45-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 381.0±37.0 °C(Predicted)
• Density: 1.849±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-bromopyrido[2,3-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromopyrido[2,3-d]pyrimidin-4-amine(1121633-45-1)
• EPA Substance Registry System: 6-bromopyrido[2,3-d]pyrimidin-4-amine(1121633-45-1)

Safety Data

• Hazardous Substances Data: 1121633-45-1(Hazardous Substances Data)

Upstream product

• 709652-82-4 2-amino-5-bromonicotinonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 1350452-23-1 2-(1-(trimethylsilyl)ethylidene)malononitrile 
• 1508-07-2 1,1-dicyanopropene 
• 1350452-24-2 2-amino-6-(methylthio)-4-(trimethylsilyl)nicotinonitrile 
• 1093963-85-9 2-amino-6-(methylthio)nicotinonitrile 
• 52833-94-0 2-amino-5-bromonicotinicacid 
• 155690-79-2 6-bromo-3H,4H-pyrido[2,3-d]pyrimidin-4-one 
• 1215787-31-7 6-bromo-4-chloropyrido[2,3-d]pyrimidine 

Downstream Products

• 1594729-05-1 6-(3-chlorophenyl)pyrido[2,3-d]pyrimidin-4-amine 
• 155690-79-2 6-bromo-3H,4H-pyrido[2,3-d]pyrimidin-4-one 
• 1215787-31-7 6-bromo-4-chloropyrido[2,3-d]pyrimidine 

Relevant articles and documents

Modular assembly of purine-like bisphosphonates as inhibitors of hiv-1 reverse transcriptase

Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer reaction and effectively inhibit RNA/DNA polymerases. In a search of HIV-1 reverse transcriptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic was synthesized. A modular synthetic protocol was developed, utilizing 2-amino-6-(methylthio)-4-(trimethylsilyl)nicotinonitrile as the key synthon in the preparation of highly substituted 2-aminonicotinonitriles. These building blocks were subsequently elaborated to the pyrido[2,3-d]pyrimidine bisphosphonates (PYPY-BPs). Biochemical screening identified analogs of PYPY-BPs that inhibit HIV-1 RT-catalyzed DNA synthesis.

2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE

The invention described herein comprises compounds of formula (IV) and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The compounds (IV) inhibit signaling by a member of the TGF-β superfamily such as Nodal or Activin.