112273-70-8

Basic information

• Product Name: N-((1H-tetrazol-5-yl)methyl)benzamide
• Synonyms: N-((1H-tetrazol-5-yl)methyl)benzamide
• CAS NO: 112273-70-8
• Molecular Weight: 203.203
• Mol File: 112273-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((1H-tetrazol-5-yl)methyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1H-tetrazol-5-yl)methyl)benzamide(112273-70-8)
• EPA Substance Registry System: N-((1H-tetrazol-5-yl)methyl)benzamide(112273-70-8)

Safety Data

• Hazardous Substances Data: 112273-70-8(Hazardous Substances Data)

Upstream product

• 31602-63-8 (1H-tetrazol-5-yl)methanamine 
• 98-88-4 benzoyl chloride 
• 5692-27-3 2-benzamido-ethanenitrile 

Downstream Products

• 118764-13-9 1H-1,2,3,4-tetrazol-5-ylmethanamine hydrochloride 

Relevant articles and documents

Design, Synthesis, and in Vitro and in Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer

Sphingosine 1-phosphate receptor 1 (S1P1) plays a pivotal signaling role in inflammatory response; because S1P1 modulation has been identified as a therapeutic target for various diseases, a PET tracer for S1P1 would be a useful tool. Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding potency measured; four had high potency and selectivity for S1P1 (S1P1 IC50 100-fold selectivity for S1P1 over S1P2 and S1P3). The most potent ligand, 28c (IC50 = 2.63 nM for S1P1) was 18F-labeled and evaluated in a mouse model of LPS-induced acute liver injury to determine its S1P1-binding specificity. The results from biodistribution, autoradiography, and microPET imaging showed higher [18F]28c accumulation in the liver of LPS-treated mice than controls. Increased expression of S1P1 in the LPS model was confirmed by immunohistochemical analysis (IHC). These data suggest that [18F]28c is a S1P1 PET tracer with high potential for imaging S1P1 in vivo.