112297-79-7 Usage
Description
Deoxy Arteether is a metabolite of Arteether and an Artemisinin analogue, which is a white solid with potent antimalarial properties.
Uses
Used in Pharmaceutical Industry:
Deoxy Arteether is used as an antimalarial agent for its ability to effectively treat malaria infections. It is a valuable component in the development of new antimalarial drugs due to its potent activity against the Plasmodium parasite responsible for causing the disease.
Used in Research and Development:
Deoxy Arteether is used as a research compound for studying the mechanisms of action and potential applications of Artemisinin and its derivatives in the treatment of various diseases, including malaria. Its unique chemical properties and biological activity make it an important tool in the ongoing search for new and improved therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 112297-79-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,2,9 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112297-79:
(8*1)+(7*1)+(6*2)+(5*2)+(4*9)+(3*7)+(2*7)+(1*9)=117
117 % 10 = 7
So 112297-79-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H28O4/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1
112297-79-7Relevant articles and documents
Arteether, a new antimalarial drug: Synthesis and antimalarial properties
Brossi,Venugopalan,Gerpe,Yeh,Flippen-Anderson,Buchs,Luo,Milhous,Peters
, p. 645 - 650 (2007/10/02)
Arteether (6) has been prepared from dihydroqinghaosu (3) by etherification with ethanol in the presence of Lewis acid and separated from its chromatographically slower moving α-dihydroqinghaosu ethyl ether (7). The absolute stereochemistry at C-12 has been determined by 1H NMR data (J11,12, NOESY). Ethyl ethers 6 and 7 showed potent in vitro inhibition of Plasmodium falciparum, and both compounds were highly potent antimalarials in mice infected with a drug-sensitive strain of Plasmodium berghei. Crystalline arteether (6) and its oily epimer 7 were 2-3 times more potent schizontocides than qinghaosu (1), but deoxy compounds 8, 9, and 11 were 100-300 times less potent in vitro than their corresponding peroxy precursors. Pharmacological studies have shown arteether (6) to have antimalarial activity in animals comparable to artesunate (2) and artemether (4), both of which are fast-acting blood schizontocides in humans. Arteether (6) has now been chosen for a clinical evaluation in high-risk malaria patients.
