112676-08-1

Basic information

• Product Name: N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine
• Synonyms: N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine
• CAS NO: 112676-08-1
• Molecular Weight: 282.732
• Mol File: 112676-08-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine(112676-08-1)
• EPA Substance Registry System: N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine(112676-08-1)

Safety Data

• Hazardous Substances Data: 112676-08-1(Hazardous Substances Data)

Upstream product

• 75415-01-9 3-(dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 
• 6145-41-1 3-chlorophenylguanidine 
• 55314-16-4 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 

Relevant articles and documents

Potent and selective inhibitors of the Abl-kinase: Phenylaminopyrimidine (PAP) derivatives

Due to its relatively clear etiology, chronic myelogenous leukemia (CML) represents an ideal disease target for a therapy using a selective inhibitor of the Bcr-Abl tyrosine protein kinase. Extensive optimization of the class of phenylamino-pyrimidines yielded highly potent and selective Bcr-Abl kinase inhibitors. Compound 1 shows high potency (IC50 = 38 nM) and selectivity for the Abl tyrosine protein kinase at the in vitro level.