1126906-51-1

Basic information

• Product Name: (R)-diethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate
• Synonyms: (R)-diethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate
• CAS NO: 1126906-51-1
• Molecular Weight: 326.777
• Mol File: 1126906-51-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-diethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-diethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate(1126906-51-1)
• EPA Substance Registry System: (R)-diethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate(1126906-51-1)

Safety Data

• Hazardous Substances Data: 1126906-51-1(Hazardous Substances Data)

Upstream product

• 105-53-3 diethyl malonate 
• 56578-37-1 3-(3-chlorophenyl)acrylaldehyde 

Downstream Products

• 1332624-52-8 (S)-ethyl 4-(3-chlorophenyl)-6-hydroxy-3,4-dihydro-2H-pyran-5-carboxylate 

Relevant articles and documents

Enantioselective β-Alkylation of Aldehydes through an Organocatalyzed C-C Bond-Scission Reaction

A novel organocatalyzed C-C bond-scission reaction of saturated aldehydes containing a suitable leaving group at the β-position was used for the in situ formation of iminium intermediates, which were then captured by nucleophiles to achieve a direct enantioselective β-alkylation of aldehydes. Within short reaction times, the corresponding β-alkylated aldehyde products were obtained in high yields (48-87%) and with excellent enantioselectivities (84-98%).

Base-base bifunctional catalysis: A practical strategy for asymmetric Michael addition of malonates to α,β-unsaturated aldehydes

Lewis base-Bronsted base bifunctional catalysis is a novel and practical strategy for the asymmetric Michael addition. The addition of malonates to a series of α,β-unsaturated aldehydes can take place under base-base bifunctional catalytic conditions using 0.5-5 mol% of (S)-2-[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as catalyst and 5-30 mol% of lithium 4-fluorobenzoate as additive base with up to 99% ee.