1133835-06-9

Basic information

• Product Name: 3,5,7-trihydroxy-2-phenylchroman-4-one
• Synonyms: 3,5,7-trihydroxy-2-phenylchroman-4-one
• CAS NO: 1133835-06-9
• Molecular Weight: 272.257
• Mol File: 1133835-06-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3,5,7-trihydroxy-2-phenylchroman-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,7-trihydroxy-2-phenylchroman-4-one(1133835-06-9)
• EPA Substance Registry System: 3,5,7-trihydroxy-2-phenylchroman-4-one(1133835-06-9)

Safety Data

• Hazardous Substances Data: 1133835-06-9(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 82451-30-7 3-phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one 
• 36804-11-2 2,4,6-tri-MOM phloracetophenone 
• 111441-88-4 Pinocembrin diacetate 
• 70651-39-7 2-Hydroxy-4,6-dibenzyloxy-dibenzoylbenzyloxymethan 
• 96335-74-9 Pentahydroxy-α,β,2',4',6'-dihydrochalcone 

Downstream Products

• 548-82-3 pinobanksin 
• 6665-78-7 5,7-di-O-acetyl chrysin 

Relevant articles and documents

Method for preparing pinobanksin from 2, 4, 6-trihydroxyacetophenone

The invention relates to a method for preparingpinobanksin from 2, 4, 6-trihydroxyacetophenone, which sequentially comprises an etherification step (A), a benzaldehyde addition step (B), a hydrogen peroxide oxidation step (C) and an acidolysis step (D). According to the preparation method disclosed by the invention, the used raw materials are easy to obtain, the reaction conditions are mild, few byproducts are produced, the yield is up to 80% or above, the product purity is up to 98.5% or above, the whole preparation process has little pollution to the environment, and the technical problem ofartificially synthesizingpinobanksin, which is not solved by people all the time, is solved.

Design, synthesis and anti-inflammatory activity of dihydroflavonol derivatives

Thirty dihydroflavonol derivatives (D1–D30) were designed and synthesized, meanwhile the synthesized compounds were characterized on the basis of spectroscopic analyzes. Their inhibitory activity against the pro-inflammatory inducible interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages were evaluated and showed various efficiency. Compounds D1–D30 showed no toxic effects on RAW 264.7 cells at the concentration 20 μM; among them, compounds D9, D13, and D19 exhibited best anti-inflammatory activity through decreasing IL-1β, IL-6, and TNF-α. Furthermore, their structure–activity relationships were discussed preliminarily.

Synthesis and structure of dihydroα,β,2',4',6'-pentahydroxychalcone

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