1134193-44-4Relevant articles and documents
Pd-catalysed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-chloroacetamides
Yin, Fangling,Feng, Gaofeng,Song, Qingbao,Qi, Chenze
experimental part, p. 41 - 44 (2012/04/04)
A Pd-catalysed cascade protocol, consisting of intermolecular O-alkylation and spontaneous intramolecular amidation, has been established for efficient synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-chloroacetamides. A varity of substrates afford the desired products in good to excellent yields. It is particularly attractive for synthesis of a library of 2H-1,4-benzoxazin-3-(4H)-ones.