113427-24-0 Usage
Description
EPOETIN ALFA, also known as Epogen or Procrit, is a recombinant human erythropoietin produced in Chinese hamster ovary cells. The human erythropoietin gene is inserted into these cells, which glycosylate the protein in a manner similar to that observed in human cells. EPOETIN ALFA is a hormone that stimulates the production of red blood cells and is used to treat various types of anemia.
Used in Anti-anemic Applications:
EPOETIN ALFA is used as an anti-anemic agent for patients with chronic renal failure, including those who require regular dialysis and those who do not. It helps increase the production of red blood cells, alleviating the symptoms of anemia and improving the overall quality of life for these patients.
Used in Hematinic Applications:
EPOETIN ALFA is also used as a hematinic in anemia associated with AIDS, treatment of AIDS with zidovudine, frequent blood donations, and neoplastic diseases. It helps maintain healthy red blood cell levels, ensuring proper oxygen transport and supporting the body's overall health.
Used in Blood Donation Industry:
EPOETIN ALFA is used as a preventive measure for anemia in patients who donate blood prior to surgery for future autologous transfusions. It helps maintain adequate red blood cell levels, reducing the risk of complications and promoting faster recovery.
Used in Medical Transfusions:
EPOETIN ALFA is used to reduce the need for repeated maintenance transfusions in patients with chronic anemia. By stimulating the production of red blood cells, it helps minimize the frequency of transfusions and the associated risks.
The hormone is available as an isotonic buffered solution, which is administered by the intravenous route. The solution should not be frozen or shaken and is stored at 36°F to 46°F. Brand names for EPOETIN ALFA include Epogen (Amgen) and Procrit (Ortho Biotech).
Clinical Use
Epoetin Alfa, recombinant Erythropoietin alfa, Epogen,Procrit, is a glycoprotein that stimulates red blood cellproduction. It is produced in the kidney, and it activates theproliferation and differentiation of specially committed erythroidprogenitors in the bone marrow.Epoetin is indicated to treat anemia of chronic renal failurepatients, anemia in zidovudine-treated HIV-infectedpatients, and in cancer patients taking chemotherapy. Theresults in these cases have been dramatic; most patients respondwith a clinically significant increase in hematocrit.
Veterinary Drugs and Treatments
EPO has been used to treat dogs and cats for anemia associated with
chronic renal
failure. Some clinicians state that because of the expense
and potential risks associated with its use, PCV’s should be in
the “teens” before considering beginning EPO therapy. Development
of antibodies to EPO has severely limited its clinical usefulness in
veterinary medicine for chronic use. EPO may be demonstrated in
the future to have significant benefits in reducing the number or
volume of transfusions, or as a neuroprotective agent.
Drug interactions
Potentially hazardous interactions with other drugs
Hyperkalaemia with ACE inhibitors and
angiotensin-II antagonists
Metabolism
The metabolic fate of both endogenous and recombinant
erythropoietin is poorly understood. Current evidence
from studies in animals suggests that hepatic metabolism
contributes only minimally to elimination of the intact
hormone, but desialylated epoetin (i.e. terminal sialic
acid groups removed) appears to undergo substantial
hepatic clearance via metabolic pathways and/or binding.
Desialylation and/or removal of the oligosaccharide side
chains of erythropoietin appear to occur principally in
the liver; bone marrow also may have a role in catabolism
of the hormone. Elimination of desialylated drug by the
kidneys, bone marrow, and spleen also may occur; results
of animal studies suggest that proximal renal tubular
secretion may be involved in renal elimination.
Check Digit Verification of cas no
The CAS Registry Mumber 113427-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,4,2 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 113427-24:
(8*1)+(7*1)+(6*3)+(5*4)+(4*2)+(3*7)+(2*2)+(1*4)=90
90 % 10 = 0
So 113427-24-0 is a valid CAS Registry Number.
