113471-32-2Relevant articles and documents
Preparation of Optically Active 2-Furylcarbinols by Kinetic Resolution Using the Sharpless Reagent
Kobayashi,Yuichi,Kusakabe, Masato,Kitano, Yasunori,Sato, Fumie
, p. 1586 - 1587 (1988)
Enantioselective oxidation using TBHP and an asymmetric titanium-tartrate complex provides direct access to a variety of optically active 2-furylcarbinols.
Highly Enantioselective Hydrogenation of Enol Acetates Catalyzed by Ru-TunaPhos Complexes
Wu, Shulin,Wang, Weimin,Tang, Wenjun,Lin, Min,Zhang, Xumu
, p. 4495 - 4497 (2002)
(Matrix Presented) The chiral disphosphines with tunable dihedral angles (TunaPhos) have been used for asymmetric hydrogenation of enol acetates and dihedral-angle-dependent enantioselectivities were observed. C2-TunaPhos has been proved to be effective for Ru-catalyzed asymmetric hydrogenation of electron-deficient and other enol acetates.
Asymmetric Chemoenzymatic Reductive Acylation of Ketones by a Combined Iron-Catalyzed Hydrogenation–Racemization and Enzymatic Resolution Cascade
El-Sepelgy, Osama,Brzozowska, Aleksandra,Rueping, Magnus
, p. 1664 - 1668 (2017/04/27)
A general and practical process for the conversion of prochiral ketones into the corresponding chiral acetates has been realized. An iron carbonyl complex is reported to catalyze the hydrogenation–dehydrogenation–hydrogenation of prochiral ketones. By merging the iron-catalyzed redox reactions with enantioselective enzymatic acylations a wide range of benzylic, aliphatic and (hetero)aromatic ketones, as well as diketones, were reductively acylated. The corresponding products were isolated with high yields and enantioselectivities. The use of an iron catalyst together with molecular hydrogen as the hydrogen donor and readily available ethyl acetate as acyl donor make this cascade process highly interesting in terms of both economic value and environmental credentials.
Mechanochemical Enzymatic Kinetic Resolution of Secondary Alcohols under Ball-Milling Conditions
Hernández, José G.,Frings, Marcus,Bolm, Carsten
, p. 1769 - 1772 (2016/06/01)
Mechanosynthesis is a valuable technique, offering attractive alternatives for the preparation of organic, inorganic, and organometallic products. Surprisingly, mechanochemical enzymatic transformations have only scarcely been studied until now. Here, we demonstrate the use of lipase B from Candida antarctica (CALB) in acylative kinetic resolutions of secondary alcohols in mixer and planetary mills. Despite the mechanical stress caused by the high-speed ball milling, the biocatalyst proved highly effective, stable, and, in part, recyclable under the applied mechanochemical conditions. Best milling practice: The compatibility of lipase B from Candida antarctica (CALB) in acylative kinetic resolutions of secondary alcohols in mixer and planetary mills has been explored. Despite the mechanical stress caused by the high-speed ball milling, the biocatalyst was found to be very effective, stable, and, in part, recyclable under the applied mechanochemical conditions.