1141-58-8Relevant articles and documents
Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti- inflammatory and analgesic activities
Pau, Amedeo,Boatto, Gianpiero,Cerri, Riccardo,Palagiano, Francesco,Filippelli, Walter,Falcone, Giuseppe,Lampa, Enrico
, p. 233 - 240 (2007/10/03)
Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.