1141402-12-1

Basic information

• Product Name: N-(3-(2-chlorophenyl)-1H-pyrazol-5-yl)-2-mercaptoacetamide
• CAS NO: 1141402-12-1
• Molecular Weight: 267.739
• Mol File: 1141402-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(2-chlorophenyl)-1H-pyrazol-5-yl)-2-mercaptoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(2-chlorophenyl)-1H-pyrazol-5-yl)-2-mercaptoacetamide(1141402-12-1)
• EPA Substance Registry System: N-(3-(2-chlorophenyl)-1H-pyrazol-5-yl)-2-mercaptoacetamide(1141402-12-1)

Safety Data

• Hazardous Substances Data: 1141402-12-1(Hazardous Substances Data)

Upstream product

• 68-11-1 mercaptoacetic acid 
• 126520-01-2 5-amino-3-(2-chlorophenyl)-1H-pyrazole 

Relevant articles and documents

Botulinum neurotoxin serotype A inhibitors: Small-molecule mercaptoacetamide analogs

Botulinum neurotoxin elicits its paralytic activity through a zinc-dependant metalloprotease that cleaves proteins involved in neurotransmitter release. Currently, no drugs are available to reverse the effects of botulinum intoxication. Herein we report the design of a novel series of mercaptoacetamide small-molecule inhibitors active against botulinum neurotoxin serotype A. These analogs show low micromolar inhibitory activity against the isolated enzyme. Structure-activity relationship studies for a series of mercaptoacetamide analogs of 5-amino-3-phenylpyrazole reveal components essential for potent inhibitory activity.