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114400-37-2

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114400-37-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 114400-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,4,0 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 114400-37:
(8*1)+(7*1)+(6*4)+(5*4)+(4*0)+(3*0)+(2*3)+(1*7)=72
72 % 10 = 2
So 114400-37-2 is a valid CAS Registry Number.

114400-37-2Downstream Products

114400-37-2Relevant articles and documents

Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors

Hwang, Jong Yeon,Kim, Hee-Young,Jo, Suyeon,Park, Eunjung,Choi, Jihyun,Kong, Sunju,Park, Dong-Sik,Heo, Ja Myung,Lee, Jong Seok,Ko, Yoonae,Choi, Inhee,Cechetto, Jonathan,Kim, Jaeseung,Lee, Jinhwa,No, Zaesung,Windisch, Marc Peter

, p. 315 - 325 (2013/11/19)

In order to identify novel anti-hepatitis C virus (HCV) agents we devised cell-based strategies and screened phenotypically small molecule chemical libraries with infectious HCV particles, and identified a hit compound (1) containing a hexahydropyrimidine (HHP) core. During our cell-based SAR study, we observed a conversion of HHP 1 into a linear diamine (6), which is the active component in inhibiting HCV and exhibited comparable antiviral activity to the cyclic HHP 1. In addition, we engaged into the biological characterization of HHP and demonstrated that HHP does not interfere with HCV RNA replication, but with entry and release of viral particles. Here we report the results of the preliminary SAR and mechanism of action studies with HHP.

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