1146-44-7

Basic information

• Product Name: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate
• Synonyms: S-(4-Chlorophenyl) 4-chlorobenzenesulfonothioate
• CAS NO: 1146-44-7
• Molecular Formula: C₁₂H₈Cl₂O₂S₂
• Molecular Weight: 319.2267
• Mol File: 1146-44-7.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 459.9°C at 760 mmHg
• Flash Point: 231.9°C
• Density: 1.54g/cm³
• Vapor Pressure: 3.33E-08mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(1146-44-7)
• EPA Substance Registry System: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(1146-44-7)

Safety Data

• Hazardous Substances Data: 1146-44-7(Hazardous Substances Data)

Upstream product

• 53075-89-1 4-Chloro-benzenesulfinic acid 1-phenyl-meth-(E)-ylideneamide 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 2901-92-0 p-chlorophenylsulfinyl chloride 
• 121434-40-0 phenyliodonium bis(p-chlorophenylsulphonyl)methylide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 100-42-5 styrene 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 1073-67-2 4-vinylbenzyl chloride 
• 530-48-3 1,1-Diphenylethylene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 98-83-9 isopropenylbenzene 
• 106-54-7 p-Chlorothiophenol 
• 23837-11-8 α.α-Bis-(4-chlor-phenylmercapto)-4-methoxy-toluol 

Downstream Products

• 14204-31-0 2-(4-chlorophenylthio)isoindoline-1,3-dione 
• 16155-34-3 1-chloro-4-butylthiobenzene 
• 80172-60-7 7β-(4-chlorophenylthio)-deoxynupharidin-6-ol 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 29391-11-5 S-benzylisothiuronium p-chlorobenzenesulfonate 
• 3226-37-7 4-chlorophenyl thiocyanate 
• 106-54-7 p-Chlorothiophenol 
• 67207-21-0 p-chlorophenylsulfenyl bromide 
• 933-01-7 4-chloro-benzenesulfenyl chloride 
• 1323142-77-3 (S)-(+)-1-adamantylamino-2-[4-(4-chlorophenylthio)phenyl]propan-2-ol 
• 1323142-75-1 C₁₅H₁₃ClOS 
• 1323142-73-9 (S)-(+)-4-(4-chlorophenylthio)styrene oxide 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 

Relevant articles and documents

Oxidative dimerization of sulfenyl chlorides into thiosulfonates under the action of hexamethylphosphoramide

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Copper-Catalyzed Aerobic Formation of Unstable Sulfinyl Radicals for the Synthesis of Sulfinates and Thiosulfonates

Copper-catalyzed aerobic coupling of thiols and alcohols affords sulfinates and thiosulfonates. These products are assumed to form via sulfinyl radicals which are not commonly found in oxidative coupling reactions of thiols. A reaction mechanism involving sulfinyl radicals is proposed, and mass and electron paramagnetic resonance (EPR) experimental results are provided.

Zinc dichromate trihydrate (ZnCrmiddot;3H) as an efficient reagent for the one-pot synthesis of thiosulfonates from thiols

ZnCrH is a readily available and efficient reagent for the one-pot synthesis of a variety of thiosulfonates by chemoselective oxidation of thiols. Georg Thieme Verlag Stuttgart New York.

Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives

A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, thiosulfonates were well driven to achieve the bifunctionalization reaction of oxo-1,7-enynes which derived from aliphatic alkynes. In addition, the (E)-configuration of the products was highly controlled by the structure of 1,7-enyne.

Synthesis of Symmetrical Thiosulfonates via Cu(OTf)2-Catalyzed Reductive Homocoupling of Arenesulfonyl Chlorides

A variety of symmetrical thiosulfonates are synthesized via Cu-catalyzed reductive homocoupling of aryl sulfonyl chlorides. This protocol uses organic amine acting as a mild reductant and low-cost copper as an effective catalyst. Such a reductive coupling process features a broad substrate scope and good functional group tolerance. Related thiosulfonate products can also be converted into diverse functional molecules.

Synthesis of symmetrical / unsymmetrical thiosulfonates through the disproportionate coupling reaction of sulfonyl hydrazide mediated by phosphomolybdic acid

Phosphomolybdic acid (H3PMo12O40) is reported as a green low-cost catalyst for the synthesis of symmetrical / unsymmetrical thiosulfonates via the disproportionate coupling reaction of sulfonyl hydrazide. The attributes of this reported catalytic system include low catalyst loadings (1 mol%), efficient turnover, and high yields (up to 94%). Additionally, this reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via sulfinyl radical disproportionation.