1146629-75-5 Usage
Description
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate is a heterocyclic compound characterized by its unique chemical structure, which features a pyrrolo[2,3-d]pyrimidine core with a chlorine atom at the 4-position and a pivalate group attached to the 7-position. This molecule is of interest in the field of pharmaceutical chemistry due to its potential applications in the synthesis of various drugs.
Uses
Used in Pharmaceutical Synthesis:
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate is used as a heterocyclic derivative for pharmaceutical synthesis. Its unique chemical structure makes it a valuable building block for the development of new drugs, particularly those targeting specific biological pathways or receptors. The presence of the chlorine atom and the pivalate group allows for further functionalization and modification, enabling the creation of a diverse range of pharmaceutically relevant compounds.
In the pharmaceutical industry, (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate is used as a key intermediate in the synthesis of various therapeutic agents. Its incorporation into drug molecules can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability. Additionally, this compound may be utilized in the development of novel drugs for the treatment of various diseases, including cancer, neurological disorders, and infectious diseases, among others.
Furthermore, (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate can also be employed in the design of prodrugs, which are biologically inactive compounds that are converted into active drugs within the body. This approach can improve the pharmacokinetic properties of the final drug, such as its solubility, stability, and absorption, ultimately leading to better therapeutic outcomes for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1146629-75-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,6,2 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1146629-75:
(9*1)+(8*1)+(7*4)+(6*6)+(5*6)+(4*2)+(3*9)+(2*7)+(1*5)=165
165 % 10 = 5
So 1146629-75-5 is a valid CAS Registry Number.
1146629-75-5Relevant articles and documents
Synthesis and Characterization of Compounds Potentially Related to the Janus Kinase Inhibitor Baricitinib
Dasari,Seelam,Jayachandra,Vadali,Yerva,Tondepu,Gadakar
, p. 1569 - 1574 (2019)
Nine compounds potentially related to the Janus kinase inhibitor Baricitinib have been identified, synthesized by conventional methods, and characterized by IR, 1H and 13C NMR, and mass spectral data.
Pyrrolo[2, 3-d] pyrimidine derivatives containing piperidine as well as preparation and application thereof
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Paragraph 0121; 0122; 0123, (2020/09/16)
The invention relates to a piperidine-containing pyrrolo[2, 3-d] pyrimidine derivative as shown in a general formula I or a general formula II as well as a use method and a preparation method thereof.The invention also relates to a strong JAK kinase inhibition effect of the compound shown in the general formula I or II, the invention also relates to an application of the compound in preparation of medicines for treating and/or preventing diseases caused by abnormal expression of JAK, and particularly relates to application of the compound in preparation of medicines for treating inflammatory/autoimmune diseases, fibrosis and cancers.
JAK KINASE INHIBITOR AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0096; 0097, (2019/12/10)
Provided in the present invention are a new type JAK kinase selective inhibitor and a preparation method and the use thereof. In particular, disclosed are a compound having the structure as shown in chemical formula (I) as a JAK kinase inhibitor or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt, a hydrate or a solvate thereof.
