114873-07-3

Basic information

• Product Name: BOC-L-4-Trifluoromethylphe
• Synonyms: 4-(TRIFLUOROMETHYL)-L-PHENYLALANINE, BOC PROTECTED;L-4-(TRIFLUOROMETHYL)PHENYLALANINE, BOC PROTECTED;BOC-PHE(4-CF 3)-OH;BOC-L-PHE(4-TRIFLUOROMETHYL)-OH;BOC-4-(TRIFLUOROMETHYL)-L-PHENYLALANINE;BOC-L-4-TRIFLUOROMETHYLPHE;BOC-L-4-TRIFLUOROMETHYLPHENYLALANINE;Benzyloxycarbonyl-L-4-trifluoromethylphenylalanine
• CAS NO: 114873-07-3
• Molecular Formula: C₁₅H₁₈F₃NO₄
• Molecular Weight: 333.3
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;a-amino
• Mol File: 114873-07-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 118-137°C
• Boiling Point: 431.4 °C at 760 mmHg
• Flash Point: 214.7 °C
• Appearance: /
• Density: 1.271 g/cm³
• Vapor Pressure: 3.29E-08mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Keep Cold
• PKA: 3.76±0.10(Predicted)
• BRN: 5617499
• CAS DataBase Reference: BOC-L-4-Trifluoromethylphe(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-4-Trifluoromethylphe(114873-07-3)
• EPA Substance Registry System: BOC-L-4-Trifluoromethylphe(114873-07-3)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 114873-07-3(Hazardous Substances Data)

Usage

Description

BOC-L-4-Trifluoromethylphe, also known as N-(tert-Butoxycarbonyl)-4-trifluoromethyl-L-phenylalanine, is a valuable compound in the field of pharmaceuticals and biochemistry. It is a derivative of L-phenylalanine, an essential amino acid, with a trifluoromethyl group substitution at the 4th position and a tert-butoxycarbonyl (BOC) protecting group. BOC-L-4-Trifluoromethylphe is known for its unique properties and potential applications in the development of various pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
BOC-L-4-Trifluoromethylphe is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure allows for the development of novel compounds with enhanced properties and improved efficacy.
Used in the Preparation of Ring Substituted Phenylalanines and Tryptophans:
BOC-L-4-Trifluoromethylphe serves as a key building block in the synthesis of ring-substituted phenylalanines and tryptophans. These amino acid derivatives are important components in the development of new drugs and bioactive molecules.
Used in the Preparation of Proline Derivatives:
BOC-L-4-Trifluoromethylphe is also utilized in the preparation of proline derivatives with inhibitory action against dipeptidyl peptidase IV (DPP-IV). DPP-IV inhibitors are of significant interest in the pharmaceutical industry due to their potential in treating type 2 diabetes and other related metabolic disorders.

InChI:InChI=1/C15H18F3NO4/c1-14(2,3)23-13(22)19-11(12(20)21)8-9-4-6-10(7-5-9)15(16,17)18/h4-7,11H,8H2,1-3H3,(H,19,22)(H,20,21)/t11-/m0/s1

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 3832-75-5 (S)-4-trifluoromethylphenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 125218-25-9 (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-(4-trifluoromethyl-phenyl)-propionylamino]-4-methyl-pentanoic acid; hydrochloride 
• 119744-87-5 [(S)-1-Carbamoyl-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 142995-32-2 tert-butyl (S)-(1-(benzyl(methyl)amino)-1-oxo-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate 
• 949908-59-2 [1-(methoxy-methyl-carbamoyl)-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 911787-18-3 [1-formyl-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 949908-61-6 (S)-2-Amino-N-[(S)-2-ethylcarbamoyl-2-hydroxy-1-(4-trifluoromethyl-benzyl)-ethyl]-3-methyl-butyramide 
• 949908-65-0 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-2-ethylcarbamoyl-2-hydroxy-1-(4-trifluoromethyl-benzyl)-ethylcarbamoyl]-2-methyl-propyl}-amide 
• 143016-41-5 (2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(4-trifluoromethyl-phenyl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 119744-82-0 (S)-2-Ethylamino-3-(4-trifluoromethyl-phenyl)-propionamide 
• 119769-38-9 ({[(S)-1-Carbamoyl-2-(4-trifluoromethyl-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamic acid tert-butyl ester 
• 119745-76-5 [(S)-1-{(R)-1-[({[(S)-1-Carbamoyl-2-(4-trifluoromethyl-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamoyl]-4-guanidino-butylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 944470-71-7 tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate 
• 1105710-25-5 (S)-tert-butyl 1-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-oxo-3-(4-(trifluoromethyl)phenyl)propan-2-ylcarbamate 

Relevant articles and documents

N-acylamino acid amide compounds and intermediates for preparation thereof

The present invention discloses the compound represented by the formula (I): wherein A represents the following formula (a-1) or the following formula (a-2): B represents the following formula (b): (wherein the symbols are each as defined in the specification) or a pharmaceutically acceptable salts thereof, and intermediates for the preparation thereof, which have excellent platelet aggregation inhibitory activity and other properties and useful as prophylactic or therapeutic agents for diseases associated with a fibrinogen receptor, thrombosis, infarction and the like.

Amino acids and peptides. X. Leu-enkephalin analogues containing a fluorinated aromatic amino acid

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