115029-22-6 Usage
Description
2-Fluoro-3-(trifluoromethyl)benzoic acid is a white to beige crystalline powder that is a derivative of benzoic acid with a fluorine atom at the 2nd position and a trifluoromethyl group at the 3rd position. 2-FLUORO-3-(TRIFLUOROMETHYL)BENZOIC ACID is known for its unique chemical properties and potential applications in various fields.
Uses
Used in Chemical Synthesis:
2-Fluoro-3-(trifluoromethyl)benzoic acid is used as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and reactivity make it a valuable building block for the development of new compounds with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoro-3-(trifluoromethyl)benzoic acid is used as a starting material for the synthesis of various drug candidates. Its presence in the molecular structure can impart specific biological activities, such as improved potency, selectivity, or metabolic stability, making it an important component in the development of new therapeutic agents.
Used in Agrochemical Industry:
2-Fluoro-3-(trifluoromethyl)benzoic acid is also utilized in the agrochemical industry for the synthesis of novel pesticides and herbicides. The introduction of fluorine and trifluoromethyl groups can enhance the lipophilicity, volatility, and biological activity of the resulting compounds, leading to more effective and targeted pest control solutions.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-Fluoro-3-(trifluoromethyl)benzoic acid is employed in the production of various high-performance materials, such as polymers, dyes, and coatings. Its unique chemical properties can contribute to improved performance characteristics, such as increased thermal stability, chemical resistance, or UV resistance, making it a valuable component in the development of advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 115029-22-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,0,2 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115029-22:
(8*1)+(7*1)+(6*5)+(5*0)+(4*2)+(3*9)+(2*2)+(1*2)=86
86 % 10 = 6
So 115029-22-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H4F4O2/c9-6-4(7(13)14)2-1-3-5(6)8(10,11)12/h1-3H,(H,13,14)/p-1
115029-22-6Relevant articles and documents
Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors
Qin, Donghui,Lin, Xiaojuan,Liu, Zhi,Chen, Yan,Zhang, Zhiliu,Wu, Chengde,Liu, Linlin,Pan, Yan,Laquerre, Sylvie,Emery, John,Fergusson, Jeff,Roland, Kimberly,Keenan, Rick,Oliff, Allen,Kumar, Sanjay,Cheung, Mui,Su, Dai-Shi
, p. 1005 - 1010 (2021)
We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation of the structure-activity relationship of the lead compound 1g led to truncated analogues that have good potency in cells, pharmacokinetic (PK) properties, and excellent selectivity. Compound 21 exhibited excellent potencies in cells and proliferation studies, good selectivity, in vitro activities, and an excellent PK profile. Compound 21 also inhibited H292 xenograft tumor growth in nude mice. The synthesis, biological, pharmacokinetic, in vivo efficacy studies, and safety profiles of compounds are presented.
P2X7 MODULATORS
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Paragraph 0284; 0286, (2014/09/29)
The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.
INHIBITORS OF STEAROYL-COA DESATURASE
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, (2009/06/27)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
