115058-61-2

Basic information

• Product Name: 17α-(3'-amino-1'-propyn-1'-yl)-1,3,5(10)-estratriene-3,17β-diol 3-(p-hydroxyphenyl)propionamide
• CAS NO: 115058-61-2
• Molecular Weight: 473.612
• Mol File: 115058-61-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17α-(3'-amino-1'-propyn-1'-yl)-1,3,5(10)-estratriene-3,17β-diol 3-(p-hydroxyphenyl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 17α-(3'-amino-1'-propyn-1'-yl)-1,3,5(10)-estratriene-3,17β-diol 3-(p-hydroxyphenyl)propionamide(115058-61-2)
• EPA Substance Registry System: 17α-(3'-amino-1'-propyn-1'-yl)-1,3,5(10)-estratriene-3,17β-diol 3-(p-hydroxyphenyl)propionamide(115058-61-2)

Safety Data

• Hazardous Substances Data: 115058-61-2(Hazardous Substances Data)

Upstream product

• 115058-58-7 17α-<3'-(2'',5''-dimethyl-1''-pyryl)-1'-propyn-1'-yl>-1,3,5(10)-estratriene-3,17β-diol 3-tetrahydropyranyl ether 
• 115058-59-8 17α-<3'-(2'',5''-dimethyl-1''-pyryl)-1'-propyn-1'-yl>-1,3,5(10)-estratriene-3,17β-diol 
• 7103-48-2 3-tetrahydropyranyloxy-1,3,5⁽¹⁰⁾-estratrien-17-one 
• 34071-95-9 N-succinimidyl-3-(p-hydroxyphenyl)propionate 
• 115058-60-1 estrynamine 

Relevant articles and documents

CONJUGATES OF STEROIDS AND ANTI-CANCER AGENTS. III. THE SYNTHESIS OF ESTRYNAMINE AND CERTAIN DERIVATIVES

Propargyl amine was protected by condensing it with 2,5-hexanedione to give 2,5-dimethyl-N-(2'-propyn-1'-yl)pyrrole (2).The latter was converted to the corresponding Grignard reagent with ethylmagnesium bromide, and then condensed with estrone tetrahydropyranyl ether to give 17α--1,3,5(10)-estratriene-3,17β-diol 3-tetrahydropyranyl ether (3), in 85percent yield.Acetic acid and methanol cleaved the tetrahydropyranyl ether group, and hydroxylamine and sodium bicarbonate cleaved the pyrrole ring to give 17α-(3'-amino-1'-propyn-1'-yl)-1,3,5(10)-estratriene-3,17β-diol (1), estrynamine.Several derivatives and analogs of 1 were also synthesized.Estrynamine binds to estrogen receptor with an RBA of 0.0045 (estradiol = 1.0).Several of the compounds, including estrynamine, are weak estrogens (stimulation of prolactin synthesis).