115256-44-5 Usage
Description
1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane, also known as N''-Desaminomethylsulfonyl-N''-nitryl Dofetilide, is a chemical compound derived from Dofetilide, a potassium channel blocker. It is characterized by its complex molecular structure, which includes a methanesulphonamidophenoxy group and a nitrophenethylamino group.
Uses
Used in Pharmaceutical Industry:
1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane is used as an impurity in the production of Dofetilide, a potassium channel blocker. Its presence in the final product can affect the drug's efficacy and safety, making it crucial to monitor and control its levels during the manufacturing process.
Used in Quality Control and Analysis:
As an impurity of Dofetilide, 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane is used in quality control and analytical processes to ensure the purity and potency of the final drug product. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry can be employed to detect and quantify its presence in Dofetilide samples.
Used in Research and Development:
1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane can also be utilized in research and development efforts to better understand the properties and effects of Dofetilide and its related compounds. By studying the behavior of N''-Desaminomethylsulfonyl-N''-nitryl Dofetilide, scientists can gain insights into the structure-activity relationships of potassium channel blockers and potentially develop new, more effective drugs with improved safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 115256-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,2,5 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115256-44:
(8*1)+(7*1)+(6*5)+(5*2)+(4*5)+(3*6)+(2*4)+(1*4)=105
105 % 10 = 5
So 115256-44-5 is a valid CAS Registry Number.
115256-44-5Relevant articles and documents
Computer-aided design, synthesis and biological assay of p-methylsulfonamido phenylethylamine analogues
Liu, Hong,Ji, Min,Jiang, Hualiang,Liu, Ligang,Hua, Weiyi,Chen, Kaixian,Ji, Ruyun
, p. 2153 - 2157 (2007/10/03)
Class III antiarrhythmic agents selectively delay the effective refractory period (ERP) and increase the transmembrance action potential duration (APD). Based on our previous studies, a set of 17 methylsulfonamido phenylethylamine analogues were investigated by 3D-QSAR techniques of CoMFA and CoMSIA. The 3D-QSAR models proved a good predictive ability, and could describe the steric, electrostatic and hydrophobic requirements for recognition forces of the receptor site. According to the clues provided by this 3D-QSAR analysis, we designed and synthesized a series of new analogues of methanesulfonamido phenylethylamine (VI(a-i)). Pharmacological assay indicated that the effective concentrations of delaying the functional refractory period (FRP) 10ms of these new compounds have a good correlation with the 3D-QSAR predicted values. It is remarkable that the maximal percent change of delaying FRP in μM of compound VI(c) is much higher than that of dofetilide. The results showed that the 3D-QSAR models are reliable. (C) 2000 Elsevier Science Ltd.
