1154-59-2 Usage
Description
3,3',4',5-TETRACHLOROSALICYLANILIDE is a salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety. It is an off-white to beige crystalline powder known for its bacteriostatic properties.
Uses
Used in Personal Care Industry:
3,3',4',5-TETRACHLOROSALICYLANILIDE is used as a bacteriostat for [application reason] in shampoos, surgical and laundry soaps, polishes, rinses, and deodorants. Its bacteriostatic properties help maintain cleanliness and hygiene in these products.
Used in Industrial Applications:
3,3',4',5-TETRACHLOROSALICYLANILIDE is used as a preservative in various industrial applications, such as textile finishes, cutting oils, and plastics. Its ability to inhibit bacterial growth helps prevent spoilage and degradation of these materials.
Used in Cooling Fluids:
3,3',4',5-TETRACHLOROSALICYLANILIDE is used in cooling fluids to prevent bacterial growth that can lead to system fouling and reduced efficiency.
However, it is important to note that the use of 3,3',4',5-TETRACHLOROSALICYLANILIDE in foods, drugs, and cosmetics may be restricted due to potential health and safety concerns.
Check Digit Verification of cas no
The CAS Registry Mumber 1154-59-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1154-59:
(6*1)+(5*1)+(4*5)+(3*4)+(2*5)+(1*9)=62
62 % 10 = 2
So 1154-59-2 is a valid CAS Registry Number.
1154-59-2Relevant articles and documents
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase
Liu, Yaya,Donner, Pamela L.,Pratt, John K.,Jiang, Wen W.,Ng, Teresa,Gracias, Vijaya,Baumeister, Steve,Wiedeman, Paul E.,Traphagen, Linda,Warrior, Usha,Maring, Clarence,Kati, Warren M.,Djuric, Stevan W.,Molla, Akhteruzzaman
scheme or table, p. 3173 - 3177 (2009/04/11)
Halosalicylamide derivatives were identified from high-throughput screening as potent inhibitors of HCV NS5B polymerase. The subsequent structure and activity relationship revealed the absolute requirement of the salicylamide moiety for optimum activity. Methylation of either the hydroxyl group or the amide group of the salicylamide moiety abolished the activity while the substitutions on both phenyl rings are acceptable. The halosalicylamide derivatives were shown to be non-competitive with respect to elongation nucleotide and demonstrated broad genotype activity against genotype 1-3 HCV NS5B polymerases. Inhibitor competition studies indicated an additive binding mode to the initiation pocket that is occupied by the thiadiazine class of compounds and an additive binding mode to the elongation pocket that is occupied by diketoacids, but a mutually exclusive binding mode with respect to the allosteric thumb pocket that is occupied by the benzimidazole class of inhibitors. Therefore, halosalicylamides represent a novel class of allosteric inhibitors of HCV NS5B polymerase.
