115453-82-2 Usage
Description
7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic compound that serves as a substrate for monitoring the activity of cytochrome P450 in various cells and research applications.
Uses
Used in Cytochrome P450 Activity Monitoring:
7-Ethoxy-4-(trifluoromethyl)coumarin is used as a fluorogenic substrate for determining cytochrome P450 activity, which plays a crucial role in the metabolism and regulation of various drugs and other compounds.
Used in In Vitro Cytotoxicity Testing:
7-ETHOXY-4-(TRIFLUOROMETHYL)COUMARIN is utilized in in vitro cytotoxicity testing to evaluate the potential toxicity of substances on cells, providing valuable information for drug development and safety assessment.
Used in Drug Metabolism and Regulation Research:
7-Ethoxy-4-(trifluoromethyl)coumarin is employed in research studies focused on drug metabolism and regulation, helping to understand the complex interactions between drugs, enzymes, and cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 115453-82-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,5 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115453-82:
(8*1)+(7*1)+(6*5)+(5*4)+(4*5)+(3*3)+(2*8)+(1*2)=112
112 % 10 = 2
So 115453-82-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3
115453-82-2Relevant articles and documents
Synthesis of 7-alkoxy-4-trifluoromethylcoumarins via the von Pechmann reaction catalyzed by molecular iodine
Degrote, Jami,Tyndall, Stephen,Wong, Koon Fai,Vanalstine-Parris, Melissa
, p. 6715 - 6717 (2014)
The synthesis of a series of 7-alkoxy-4-trifluoromethylcoumarins via the von Pechmann reaction catalyzed by molecular iodine is described. The reaction protocol is simple, inexpensive and leads to the formation of the corresponding coumarin derivatives in good yield and high purity. A key intermediate as well as several iodo byproducts were isolated.
