1155-62-0 Usage
Description
N-Cbz-L-glutamic acid, also known as N-benzyloxycarbonyl-L-glutamic acid, is a derivative of L-glutamic acid, an important non-essential amino acid found in various proteins. It is characterized by an off-white solid appearance and is widely used in the synthesis of various compounds due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
N-Cbz-L-glutamic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its role in the synthesis process is crucial, as it can be incorporated into the structure of drugs to enhance their efficacy, stability, or bioavailability.
Used in Synthesis of Carboxyalkyl Peptides:
In the field of biochemistry and drug development, N-Cbz-L-glutamic acid is used as a key component in the synthesis of carboxyalkyl peptides. These peptides serve as inhibitors of the angiotensin-converting enzyme (ACE) found in human blood serum. By inhibiting ACE, these peptides can help regulate blood pressure and are thus valuable in the development of antihypertensive medications.
Used in Organic Synthesis:
N-Cbz-L-glutamic acid is also utilized in organic synthesis for the preparation of various compounds, including those with potential applications in the fields of material science, agrochemicals, and other specialty chemicals. Its versatility and reactivity make it a valuable intermediate in the synthesis of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1155-62-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1155-62:
(6*1)+(5*1)+(4*5)+(3*5)+(2*6)+(1*2)=60
60 % 10 = 0
So 1155-62-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO6/c15-11(16)7-6-10(12(17)18)14-13(19)20-8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,19)(H,15,16)(H,17,18)/t10-/m1/s1
1155-62-0Relevant articles and documents
Effect of freezing on the enzymatic coupling of specific amino acid-containing peptide fragments
Wehofsky, Nicole,Haensler, Marion,Kirbach, Sebastian W.,Wissmann, Johannes-Dieter,Bordusa, Frank
, p. 2421 - 2428 (2000)
The effect of freezing on the enzymatic coupling of highly specific amino acid-containing peptide fragments was investigated using trypsin, α-chymotrypsin, and Bacillus licheniformis Glu-specific endopeptidase as biocatalysts. Comparison with reactions at normal temperature indicates that freezing efficiently represses the cleavage of specific peptide bonds independent of their individual localisation and specificity achieving irreversible and efficient peptide bond formation without proteolytic side reactions. Copyright (C) 2000 Elsevier Science Ltd.
PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
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Paragraph 00316; 00321, (2019/03/12)
Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.
Synthesis of fully protected (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy heptanoic acid
Yoshino, Ryo,Tokairin, Yoshinori,Konno, Hiroyuki
supporting information, p. 1604 - 1606 (2017/04/03)
(2R,3R,4S)-4-Amino-7-guanidino-2,3-dihydroxyheptanoic acid (AGDHE), a common constituent of biologically active marine peptides, callipeltin A (1) and neamphamide A, was synthesized as its orthogonally protected derivative from L-glutamic acid in 15 steps. Guanidination by the Mitsunobu condition and osmium-catalyzed dihydroxylation of the corresponding Z-olefin were employed as the key steps.
