1155847-48-5Relevant articles and documents
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase
Gomez, Robert,Jolly, Samson,Williams, Theresa,Tucker, Thomas,Tynebor, Robert,Vacca, Joe,McGaughey, Georgia,Lai, Ming-Tain,Felock, Peter,Munshi, Vandna,Destefano, Daniel,Touch, Sinoeun,Miller, Mike,Yan, Youwei,Sanchez, Rosa,Liang, Yuexia,Paton, Brenda,Wan, Bang-Lin,Anthony, Neville
, p. 7344 - 7350 (2012/02/04)
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constraint to
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 117, (2009/06/27)
Heteroaromatic compounds of Formula (I), are HIV reverse transcriptase inhibitors, wherein ring A is: (ii-a), (ii-b), (ii-c), (ii-d), or (ii-e); and wherein n, L, M, U, X, Y, Z, RE, RF, R1, R2A, R2B,