115747-35-8

Basic information

• Product Name: N-(deoxyguanosin-8-yl)-2-amino-3-methylimidazolo(4,5-f)quinoline
• Synonyms: N-(deoxyguanosin-8-yl)-2-amino-3-methylimidazolo(4,5-f)quinoline
• CAS NO: 115747-35-8
• Molecular Formula: C₂₁H₂₁N₉O₄
• Molecular Weight: 463.45
• Mol File: 115747-35-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 904.4°C at 760 mmHg
• Flash Point: 500.8°C
• Appearance: /
• Density: 1.9g/cm³
• Vapor Pressure: 3.04E-35mmHg at 25°C
• Refractive Index: 1.931
• CAS DataBase Reference: N-(deoxyguanosin-8-yl)-2-amino-3-methylimidazolo(4,5-f)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(deoxyguanosin-8-yl)-2-amino-3-methylimidazolo(4,5-f)quinoline(115747-35-8)
• EPA Substance Registry System: N-(deoxyguanosin-8-yl)-2-amino-3-methylimidazolo(4,5-f)quinoline(115747-35-8)

Safety Data

• Hazardous Substances Data: 115747-35-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H21N9O4/c1-29-11-5-4-10-9(3-2-6-23-10)15(11)24-20(29)28-21-25-16-17(26-19(22)27-18(16)33)30(21)14-7-12(32)13(8-31)34-14/h2-6,12-14,31-32H,7-8H2,1H3,(H,24,25,28)(H3,22,26,27,33)/t12-,13+,14+/m0/s1

Upstream product

• 769141-90-4 8-[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 896719-56-5 6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)-9H-purine-2,8-diamine 
• 896719-51-0 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)-9H-purine-2,8-diamine 
• 76180-96-6 2-Amino-3-methylimidazo[4,5-f]quinoline 
• 479408-23-6 O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 769141-88-0 8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 328394-26-9 O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 769141-89-1 O⁶-benzyl-8-[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 328394-28-1 N²-(1,1,4,4-tetramethyldisilylazacyclopentanyl)-O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 328394-30-5 O⁶-benzyl-8-[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-2-(2,2,5,5-tetramethyl-1-aza-2,5-disilylcyclopent-1-yl)-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]inosine 

Downstream Products

• 769141-92-6 N²-[(dimethylamino)methylene]-8-[[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-N9-[5'-O-[bis(4-methoxyphenyl)phenylmethyl]]-β-D-2'-deoxyribofuranosyl]guanine 

Relevant articles and documents

Chemical synthesis of 2′-deoxyguanosine-C8 adducts with heterocyclic amines: An application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Synthesis of 2′-deoxyguanosine-C8 adducts (dG-C8 adducts) with mutagenic/carcinogenic heterocyclic amines (HCAs) was achieved via the Buchwald-Hartwig arylamination reaction. By using tris-(dibenzylideneacetone) dipalladium (Pd2dba3)

Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ.

[structure: see text] The C8-2'-deoxyguanosine adduct of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) has been synthesized. The key step is a palladium-catalyzed N-arylation of a suitably protected 8-bromo-2'-deoxyguanosine derivative.