1157561-41-5

Basic information

• Product Name: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid
• Synonyms: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid
• CAS NO: 1157561-41-5
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.1756632
• EINECS: -0
• Mol File: 1157561-41-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 309.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.345±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.54±0.10(Predicted)
• CAS DataBase Reference: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid(1157561-41-5)
• EPA Substance Registry System: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid(1157561-41-5)

Safety Data

• Hazardous Substances Data: 1157561-41-5(Hazardous Substances Data)

Usage

Description

2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is an organic compound characterized by its cyclopropane ring fused with a phenyl group, which has a fluorine atom at the meta position. This molecule is known for its unique structural properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is used as a reactant for the preparation of N-acyl-4-(heterocyclylaminomethyl)piperidines. These compounds serve as NMDA/NR2B antagonists, which are important in the development of medications targeting neurological disorders such as Alzheimer's disease, Parkinson's disease, and chronic pain conditions. The unique structure of 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid contributes to the effectiveness of these antagonists by modulating the activity of the NMDA receptor, a key player in synaptic plasticity and neuronal function.

Upstream product

• 20595-30-6 3-Fluorocinnamic acid 
• 74325-03-4 methyl (E)-m-fluorocinnamate 
• 243665-11-4 (2E)-3-(3-fluorophenyl)-N-methoxy-N-methylmethylacrylamide 
• 456-48-4 3-Fluorobenzaldehyde 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 350-51-6 3-fluorostyrene 
• 263893-75-0 ethyl 2-(3-fluorophenyl)cyclopropane carboxylate 
• 351-46-2 3-(3-Fluorophenyl)acrylic acid ethyl ester 
• 1759-53-1 cyclopropanecarboxylic acid 

Downstream Products

• 1417656-40-6 (1S,2S)-2-(3-fluorophenyl)-cyclopropanecarboxylic acid 
• 1424142-93-7 C₃₇H₅₅FN₄O₇ 
• 1237495-00-9 (1S,2R)-2-(3-fluorophenyl)cyclopropanamine 
• 220353-83-3 (1R,2S)-2-(3-fluorophenyl)cyclopropanamine 
• 1237495-03-2 (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1S,2R/1R,2S)-2-(3-fluorophenyl)cyclopropylamino)ethoxy)pyrrolidine-1-carboxylate 
• 1237495-06-5 (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1S,2R)-2-(3-fluorophenyl)cyclopropylamino)ethoxy)pyrrolidine-1-carboxylate 
• 1424142-89-1 (3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((tert-butoxycarbonyl)((1S,2R/1R,2S)-2-(3-fluorophenyl)cyclopropyl)amino)ethoxy)pyrrolidine-1-carboxylate 
• 1424142-91-5 (3R,4R)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((tert-butoxycarbonyl)((1S,2R)-2-(3-fluorophenyl)cyclopropyl)amino)ethoxy)pyrrolidine-1-carboxylate 
• 1237494-97-1 C₁₉H₂₂FNO₃ 
• 1237494-98-2 C₁₉H₂₂FNO₃ 
• 1424142-64-2 tert-Butyl 2-(3-fluorophenyl)cyclopropylcarbamate 
• 1422435-46-8 C₁₈H₁₃FN₄O 

Relevant articles and documents

PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS

The invention includes procedures for stereoselective β-arylation of carboxylic acids having a β-carbon atom. For example, stereoselective arylation procedures include the following reactions: (I)

Oxidative ring-opening of ferrocenylcyclopropylamines to N-ferrocenylmethyl β-hydroxyamides

The in situ reduction of ferrocenyl cyclopropylimines to the corresponding amines triggers a facile oxidative ring-opening to yield the formal four-electron oxidation products: N-ferrocenylmethyl β-hydroxyamides. This process is believed to proceed via generation of a ferrocinium ion in the presence of air, leading to facile formation of a distonic radical cation that is ultimately trapped by oxygen.

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase

Inhibitors of neuronal nitric oxide synthase have been proposed as therapeutics for the treatment of different types of neurological disorders. On the basis of a cis-3,4-pyrrolidine scaffold, a series of trans-cyclopropyl- and methyl-containing nNOS inhib