115851-81-5Relevant articles and documents
Synthesis and in vitro Toxicity of d-Glucose and d-Fructose Conjugated Curcumin–Ruthenium Complexes
Pr?hl, Michael,Bus, Tanja,Czaplewska, Justyna A.,Traeger, Anja,Deicke, Michael,Weiss, Henning,Weigand, Wolfgang,Schubert, Ulrich S.,Gottschaldt, Michael
, p. 5197 - 5204 (2016)
A series of carbohydrate-conjugated bis(demethoxy)curcumin (BDC) ligands were synthesized by using the Huisgen copper(I)-catalyzed cycloaddition between azido-functionalized d-glucose and d-fructose as well as propargyl-modified BDC. The unprotected sugar ligands were treated with Ru(bpy)2Cl2to form curcumin-conjugated Ru complexes of general formula Ru(bpy)2(L)Cl. The ligands as well as Ru complexes were analyzed by NMR, IR, UV/Vis, and fluorescence spectroscopy, mass spectrometry as well as by elemental analysis (EA). Incubation of L929, HepG2 and the breast cancer cell line MDA-MB-231 revealed lower cytotoxicity of all carbohydrate-conjugated ligands compared with BDC. The Ru complexes exhibited higher cytotoxicity than the parent ligands, in particular against HepG2 cells, whereas the noncancerous L929 cell line remained unaffected. Unexpectedly, the d-fructose-conjugated ligand and its corresponding Ru complex did not show any significant toxicity against MDA-MB-231 cells.
Synthesis, characterization and anticancer activity of a series of curcuminoids and their half-sandwich ruthenium(II) complexes
Li, Peiyuan,Su, Wei,Lei, Xiaolin,Xiao, Qi,Huang, Shan
, (2017/09/01)
A series of curcuminoids (L1–L7) and their corresponding (η6-p-cymene)RuII(Cur)Cl complexes (1–7) were synthesized and characterized using 1H NMR spectroscopy, elemental analysis and high-resolution e
Significant enhancement in radical-scavenging activity of curcuminoids conferred by acetoxy substituent at the central methylene carbon
Kim, Mi Kyoung,Jeong, Wooseong,Kang, Jihoon,Chong, Youhoon
experimental part, p. 3793 - 3800 (2011/08/06)
For a compound to be a radical-trapping antioxidant, the antioxidant-derived radical must be sufficiently inert to molecular oxygen as this would generate harmful chain-propagating peroxyl radicals. Curcumin has a unique structure with phenolic hydroxyl g