1160386-25-3

Basic information

• Product Name: 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide
• Synonyms: 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide
• CAS NO: 1160386-25-3
• Molecular Weight: 558.083
• Mol File: 1160386-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide(1160386-25-3)
• EPA Substance Registry System: 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide(1160386-25-3)

Safety Data

• Hazardous Substances Data: 1160386-25-3(Hazardous Substances Data)

Upstream product

• 1160386-36-6 1-chloromethyl-3-methylbutylamine hydrochloride 
• 139481-59-7 candesartan 

Downstream Products

• 1160386-28-6 thioacetic acid S-[2-({2-ethoxy-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carbonyl}amino)-4-methylpentyl]ester 

Relevant articles and documents

DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS

The invention relates to compounds having the formula: wherein Ar, r, n, X, R2, R2′, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.