116078-74-1

Basic information

• Product Name: (+/-)-β-(2-chlorophenyl)-β-cyano-N,N-bis(1-methylethyl)-1-piperidinepentanamide
• Synonyms: (+/-)-β-(2-chlorophenyl)-β-cyano-N,N-bis(1-methylethyl)-1-piperidinepentanamide
• CAS NO: 116078-74-1
• Molecular Weight: 403.995
• Mol File: 116078-74-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-β-(2-chlorophenyl)-β-cyano-N,N-bis(1-methylethyl)-1-piperidinepentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-β-(2-chlorophenyl)-β-cyano-N,N-bis(1-methylethyl)-1-piperidinepentanamide(116078-74-1)
• EPA Substance Registry System: (+/-)-β-(2-chlorophenyl)-β-cyano-N,N-bis(1-methylethyl)-1-piperidinepentanamide(116078-74-1)

Safety Data

• Hazardous Substances Data: 116078-74-1(Hazardous Substances Data)

Upstream product

• 116078-61-6 (±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 7403-66-9 N,N-diisopropylchloroacetamide 

Relevant articles and documents

Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: Monobasic derivatives of disobutamide

Analogues of the dibasic antiarrhythmic agent disobutamide (2) were prepared and evaluated for antiarrhythmic efficacy, myocardial depression, and anticholinergic activity. The replacement of an isopropyl group in disobutamide by an acetyl group led to the monoclasic analogue SC-40230, 7a, which demonstrated good antiarrhythmic activity accompanied by less myocardial depressant and anticholinergic activities. In addition, it did not induce clear cytoplasmic vacuoles as did the parent compound. SC-40230 was chosen from among other analogues as a candidate for clinical evaluation. Other compounds prepared and evaluated included indolizidinones and a secondary amine isomer of disobutamide.