116170-84-4

Basic information

• Product Name: ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE
• Synonyms: ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE;SPECS AA-516/25012077;Ethyl 4-cyano-5-(methylsulfanyl)thiophene-2-carboxylate;Ethyl 3-cyano-2-(methylsulfanyl)thiophene-5-carboxylate;4-Cyano-5-methylsulfanylthiophene-2-carboxylic acid ethyl ester;Ethyl 4-cyano-5-(methylthio)
• CAS NO: 116170-84-4
• Molecular Formula: C9H9NO2S2
• Molecular Weight: 227.3
• Mol File: 116170-84-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 370.2 °C at 760 mmHg
• Flash Point: 177.7 °C
• Appearance: /
• Density: 1.31
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE(116170-84-4)
• EPA Substance Registry System: ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE(116170-84-4)

Safety Data

• RIDADR: UN3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 116170-84-4(Hazardous Substances Data)

Usage

Description

ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE is an organic compound that serves as a key reactant in the synthesis of various pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment.
Used in Pharmaceutical Industry:
ETHYL 4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE is used as a reactant for the preparation of thienopyrazoles, which are potent kinase inhibitors. These inhibitors play a crucial role in treating cancer by targeting specific enzymes involved in cell growth and proliferation, thereby helping to control tumor development and progression.

InChI:InChI=1/C9H9NO2S2/c1-3-12-8(11)7-4-6(5-10)9(13-2)14-7/h4H,3H2,1-2H3

Upstream product

• 116170-90-2 3-amino-4-cyano-5-(methylthio)thiophene-2-carboxylic acid ethyl ester 
• 5147-80-8 [Bis(methylthio)methylene]malononitrile 

Downstream Products

• 116170-85-5 4-cyano-5-(methylthio)thiophene-2-carboxylic acid 
• 909252-83-1 N'-methyl-N'-phenyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide 
• 909252-84-2 N'-methyl-N'-phenyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide 
• 909252-85-3 N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide 
• 909252-86-4 N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide 
• 909252-70-6 N'-methyl-N'-phenyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide 
• 909252-69-3 tert-butyl 3-amino-5-(N'-methyl-N'-phenylhydrazinocarbonyl)-thieno[2,3-c]pyrazole-1-carboxylate 
• 909252-73-9 4-bromo-N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide 
• 909252-74-0 tert-butyl 3-(4-bromobenzoylamino)-5-(N'-methyl-N'-phenylhydrazinocarbonyl)thieno[2,3-c]pyrazole-1-carboxylate 
• 909252-67-1 N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]-4-morpholin-4-ylmethylbenzamide 
• 909252-75-1 N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-ylmethyl)benzamide 
• 909252-68-2 tert-butyl 5-(N'-methyl-N'-phenylhydrazinocarbonyl)-3-(4-morpholin-4-ylmethylbenzoylamino)thieno[2,3-c]pyrazole-1-carboxylate 
• 909253-00-5 tert-butyl 5-(N'-methyl-N'-phenylhydrazinocarbonyl)-3-[3-(4-methylpiperazin-1-ylmethyl)-benzoylamino]thieno[2,3-c]pyrazole-1-carboxylate 
• 909252-76-2 tert-butyl 5-(N'-methyl-N'-phenylhydrazinocarbonyl)-3-[4-(4-methylpiperazin-1-ylmethyl)benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylate 

Relevant articles and documents

Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, Process for Preparing Them, Compositions Containing Them and Use Thereof

The present invention concerns hydrazinocarbonyl-thieno[2,3-c]pyrazoles of formula (I): wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and their use for the treatment of pathological conditions, in particular as anticancer agents.